Mindfulness-based stress reduction combined with early cardiac rehabilitation improves negative mood states and cardiac function in patients with acute myocardial infarction assisted with an intra-aortic balloon pump: a randomized controlled trial
Kemei Wu, Miaomiao Wan, Huiqin Zhou, Cui Li, Xiaomin Zhou, E. Li, Ying Li, Chengwei Liu, Li Liu
Frontiers in Cardiovascular Medicine May 31, 2023 DOI: 10.3389/fcvm.2023.1166157 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 100 |
| Population | Patients with acute myocardial infarction receiving intra-aortic balloon pump support for hemodynamic instability at Wuhan Asia Heart Hospital |
| Interventions | Mindfulness-based stress reduction (MBSR) early cardiac rehabilitation |
| Duration | Intervention performed twice a day until removal of the intra-aortic balloon pump (5–7 days) |
| Measures | Self-rating anxiety scale (SAS), self-rating depression scale (SDS), profiles of mood state scale (POMS), left ventricular ejection fraction (LVEF) measured with echocardiography |
| Topics | Anxiety Depression Meditation |
| Keywords | Acute myocardial infarction Intra-aortic balloon pump Cardiac rehabilitation Mindfulness-based stress reduction |
| Key findings | Adding mindfulness-based stress reduction to early cardiac rehabilitation in acute myocardial infarction patients with intra-aortic balloon pump support produced lower anxiety, depression, and mood disturbance scores, fewer balloon-pump-related complications, and greater improvement in left ventricular ejection fraction than cardiac rehabilitation alone. |
Abstract
ObjectiveTo investigate the clinical effects of mindfulness-based stress reduction (MBSR) intervention combined with early cardiac rehabilitation (CR) on patients with acute myocardial infarction (AMI) assisted with an intra-aortic balloon pump (IABP).MethodsA total of 100 AMI patients with IABP assistance due to hemodynamic instability at Wuhan Asia Heart Hospital were enrolled in the study. The participants were divided into two groups using the random number table method (n = 50 each group). Patients receiving routine CR were assigned to the CR control group, while patients receiving MBSR plus CR were assigned to the MBSR intervention group. The intervention was performed twice a day until the removal of the IABP (5–7 days). Each patient's level of anxiety/depression and negative mood state were evaluated before and after intervention using the self-rating anxiety scale (SAS), self-rating depression scale (SDS), and profiles of mood state scale (POMS). The results of the control and intervention groups were compared. IABP-related complications and left ventricular ejection fraction (LVEF), measured with echocardiography, were also assessed and compared between the two groups.ResultsThe SAS, SDS, and POMS scores were lower in the MBSR intervention group than in the CR control group (P < 0.05). There were also less IABP-related complications in the MBSR intervention group. LVEF was significantly improved in both groups, but the degree of LVEF improvement was more significant in the MBSR intervention group than in the CR control group (P < 0.05).ConclusionsMBSR combined with early CR intervention can assist in alleviating anxiety, depression, and other negative mood states, reduce IABP-related complications, and further improve cardiac function in AMI patients with IABP assistance.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cited by 4
- Effect of mindfulness-based interventions on anxiety, depression, and stress in patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Psychology 2024
- The effect of mindfulness meditation on depressive symptoms during the COVID-19 pandemic: a systematic review and meta-analysis. Scientific Reports August 30, 2024
- The Utilization and Potential of Mindfulness-Based Stress Reduction Therapy in Individuals Diagnosed with Acute Coronary Syndrome. Reviews in cardiovascular medicine August 1, 2024
- Yoga and Mindfulness-Based Rehabilitation After Myocardial Infarction: A Systematic Review. Healthcare April 21, 2026
Cites 13
- How Does Mindfulness Meditation Work? Proposing Mechanisms of Action From a Conceptual and Neural Perspective Perspectives on Psychological Science October 14, 2011
- Meditation experience is associated with increased cortical thickness Neuroreport November 7, 2005
- Mindfulness Interventions Annual Review of Psychology September 30, 2016
- Investigation of mindfulness meditation practitioners with voxel-based morphometry Social Cognitive and Affective Neuroscience December 3, 2007
- Impact of Mindfulness Based Stress Reduction Therapy on Myocardial Function and Endothelial Dysfunction in Female Patients with Microvascular Angina Journal of Cardiovascular Ultrasound 2017
and 8 more in the library