Meditation experience is associated with increased cortical thickness
Sara W. Lazar, Catherine E. Kerr, Rachel H. Wasserman, Jeremy R. Gray, Douglas N. Greve, Michael T. Treadway, Metta Mcgarvey, Brian T. Quinn, Jeffery A. Dusek, Herbert Benson, Scott L. Rauch, Christopher I. Moore, Bruce Fischl
Neuroreport November 7, 2005 DOI: 10.1097/01.wnr.0000186598.66243.19 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 20 |
| Population | Participants with extensive Insight meditation experience and matched controls |
| Intervention | Insight meditation |
| Topics | Default mode network Meditation Neuroplasticity |
| Keywords | Insula Interoception Prefrontal cortex Neuroimaging Audiology Electroencephalography Cognition |
| Citations | 1,707 |
| Key findings | Meditation practitioners had greater cortical thickness in the prefrontal cortex and right anterior insula compared to controls, with the prefrontal difference most pronounced in older participants, and thickness in two regions correlated with meditation experience. |
Abstract
Previous research indicates that long-term meditation practice is associated with altered resting electroencephalogram patterns, suggestive of long lasting changes in brain activity. We hypothesized that meditation practice might also be associated with changes in the brain's physical structure. Magnetic resonance imaging was used to assess cortical thickness in 20 participants with extensive Insight meditation experience, which involves focused attention to internal experiences. Brain regions associated with attention, interoception and sensory processing were thicker in meditation participants than matched controls, including the prefrontal cortex and right anterior insula. Between-group differences in prefrontal cortical thickness were most pronounced in older participants, suggesting that meditation might offset age-related cortical thinning. Finally, the thickness of two regions correlated with meditation experience. These data provide the first structural evidence for experience-dependent cortical plasticity associated with meditation practice.