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Single-dose 1cp-LSD administration for canine anxiety: a pilot study.

Luis Alberto Henríquez-Hernández, Ignacio García-Serrano, Domingo J Quintana-Hernández, Jaime Rojas-Hernández, Elisa Hernández-Álvarez, Manuel Zumbado, Tobías Fernández-Borkel, Lucas F Borkel

Veterinary research communications December 1, 2024 DOI: 10.1007/s11259-024-10542-6 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Case study Pilot study Case report Peer reviewed
Sample size 1
Population A 13-year-old female mixed-breed dog with separation anxiety
Intervention 1cp-LSD
Dose 5 µg (0.38 µg/kg)
Duration 5.5 hours
Topics Anxiety LSD
Keywords 1cp-LSD Animal behavior Animal consciousness Dogs Psychedelics
Citations 4
Key findings A single 5 µg dose of 1cp-LSD reduced anxiety in a dog without adverse effects or signs of a psychedelic experience.

Abstract

Anxiety affects 14-20% of dogs. Pharmacological treatments often fail. Psychedelics have shown to be useful for anxiety and depression in humans, but their veterinary use remains unexplored. We aimed to determine the effects of low-dose 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) administered in a single dose to a dog, to observe the effect and establish the safety of the substance. The patient was a 13-year-old female dog, weighing 13 kg, mixed breed, and spayed. A total of 5 µg was administered orally, equivalent to 0.38 µg/kg. The animal has had a history of separation related behavioral problems throughout her life. To objectively assess the degree of anxiety in the dog, a validated scale was utilized. The trial was scheduled at the house where the animal lives. The owner was present throughout the experience. Informed consent was obtained prior to the assay. The trial began at 12:15 p.m. on January 10, 2024, lasting for 5 and a half hours. The response to anxiety-inducing stimuli was equally anxious during the first two hours. From that point onwards, a significant change in the animal's behavior was observed, with no signs/mild signs of anxiety. The trial concluded without any adverse effects on the animal. The patient did not show signs of having a psychedelic experience. This is the first time that a study of this nature has been conducted and reported in the canine species. 1cp-LSD proved to be safe and exerted the desired effect on the animal's behavior, significantly reducing the patient's anxiety.

Comparable studies

Other case reports and case series on LSD for anxiety, most cited first.

Study Year Design Participants
Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD) Patients who developed persistent palinopsia after LSD ingestion 1996 Case series n = 3
LSD-Like Panic From Risperidone in Post-LSD Visual Disorder Patients with hallucinogen-persisting perception disorder (HPPD) 1996 Case study n = 3
Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects A 39-year-old female patient with severe, treatment-resistant depression and complex... 2020 Case study n = 1
LSD Overdoses: Three Case Reports Three individuals who experienced accidental LSD overdose 2020 Case series n = 3
BEHAVIOR THERAPY TO EXTINGUISH SPONTANEOUS RECURRENCES OF LSD EFFECTS A client experiencing spontaneous recurrences of LSD effects 1973 Case study n = 1

Citations in the library

Cited by 4

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