Frontiers in Veterinary Science
July 28, 2026
Yanira Suárez-Fernández, Elisa Hernández-Álvarez, Lucas F Borkel et al.
IntroductionThe adoption of emerging therapeutic approaches in veterinary medicine is likely to depend not only on scientific evidence but also on how such interventions are cognitively and attitudinally appraised by future professionals. This study aimed to assess knowledge, attitudes, and perceived risk regarding psychedelic use among veterinary students, and to examine their association with...
Veterinary sciences
January 19, 2026
Elisa Hernández-Álvarez, Cristina Canino-Quijada, Sira Roiz et al.
Shelter environments frequently expose dogs to chronic stress and anxiety, which can compromise their welfare and reduce their chances of adoption. Recent interest in psychedelic-assisted approaches has suggested potential therapeutic applications in veterinary behavioral medicine, although empirical evidence remains scarce. This study aimed to evaluate the combined effects of low-dose...
PLoS One
2026
Diego Castellano-Ramírez, Elisa Hernández-Álvarez, Lucas F Borkel et al.
Psychedelic-assisted therapy is regaining attention as a promising approach to treating mental health disorders. This research aimed to compare related factors regarding the therapeutic use of psychedelics between medical and nursing students, addressing a notable gap in existing research. A cross-sectional survey was conducted at the University of Las Palmas de Gran Canaria (Spain) during the...
Animals : an open access journal from MDPI
December 19, 2025
Elisa Hernández-Álvarez, Andrea Acosta-Dacal, Octavio P Luzardo et al.
1 citation
Low-dose psychedelics have shown potential in modulating chronic pain in humans, yet their application in veterinary medicine remains unexplored. This study protocol proposes to investigate the therapeutic potential of low-dose oral administration of 1-cyclopropionyl-D-lysergic acid diethylamide (1cp-LSD), a legal LSD analogue in certain countries, for the management of chronic pain in...
Journal of Psychiatric Research
August 1, 2025
Lucas F Borkel, Jaime Rojas-Hernández, Domingo J Quintana-Hernández et al.
4 citations
This paper highlights the ethical and epistemic challenges posed by psychedelic therapy and vindicates the importance of epistemology in the clinical and psychotherapeutic setting. Despite their relative physiological and psychological safety, these substances can induce changes in the beliefs of those who use them, such as paranormal beliefs. To explain the changes in beliefs, we introduced...
ACS Pharmacology & Translational Science
July 16, 2025
Tobías Fernández-Borkel, Lucas F Borkel, Jaime Rojas-Hernández et al.
3 citations
The therapeutic potential of psychedelic substances, particularly psilocybin, for treatment-resistant depression (TRD) has garnered considerable attention. However, the necessity of subjective psychedelic experiences for therapeutic efficacy remains unclear, creating a critical gap in the field. To determine whether subjective psychedelic experiences induced by psilocybin are required for its...
Veterinary medicine and science
July 1, 2025
Elisa Hernández-Álvarez, Lucas F Borkel, Jaime Rojas-Hernández et al.
3 citations
This pilot study explored the potential of microdosing 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) to treat canine anxiety. A single-case study was conducted on a 13-year-old female dog with severe separation anxiety, who was treated with 5 µg of 1cp-LSD every 3 days for a month. Anxiety was assessed before, after, and 1 month following treatment using a validated questionnaire. The...
Veterinary research communications
December 1, 2024
Luis Alberto Henríquez-Hernández, Ignacio García-Serrano, Domingo J Quintana-Hernández et al.
4 citations
Anxiety affects 14-20% of dogs. Pharmacological treatments often fail. Psychedelics have shown to be useful for anxiety and depression in humans, but their veterinary use remains unexplored. We aimed to determine the effects of low-dose 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) administered in a single dose to a dog, to observe the effect and establish the safety of the substance....
Current Psychology
November 21, 2024
Jaime Rojas-Hernández, Lucas F Borkel, Domingo Jesús Quintana Hernández et al.
6 citations
Abstract Psychedelic use has increased in the last decade. However, it is unclear whether the cultural background of the consumers exerts any influence. The aim of the present study was to determine the pattern of psychedelic use in Spain and Spanish-speaking populations in South America and compare these consumption patterns to understand the use of these substances in two culturally distinct...
Expert Review of Clinical Pharmacology
2024
Lucas F Borkel, Jaime Rojas-Hernández, Luis Alberto Henríquez-Hernández et al.
40 citations
In psychedelic therapy, the importance of set and setting is a fundamental but under-researched assumption. The aim of this study is to correlate variables of set (psychedelic use motivation) and setting (psychedelic use location and type of companion) with psychopathology, wellbeing and personality variables. A sample of 1022 participants of the Spanish-speaking population was collected...
Toxics
February 3, 2023
Luis Alberto Henríquez-Hernández, Jaime Rojas-Hernández, Domingo Jesús Quintana Hernández et al.
21 citations
Psychedelics are experiencing a strong renaissance and will soon be incorporated into clinical practice. However, there is uncertainty about how much harm they can cause at what doses. This review aimed to collect information on the health-hazardous doses of psychedelic substances, to be aware of the risks to which patients may be subjected. We focused on ergolamines, simple tryptamines, and...