LSD-Like Panic From Risperidone in Post-LSD Visual Disorder
Henry David Abraham, Anitra Mamen
Journal of Clinical Psychopharmacology June 1, 1996 DOI: 10.1097/00004714-199606000-00008 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 3 |
| Population | Patients with hallucinogen-persisting perception disorder (HPPD) |
| Intervention | Risperidone |
| Topics | Anxiety LSD |
| Keywords | Risperidone |
| Citations | 50 |
| Key findings | Three HPPD patients treated with risperidone reported an exacerbation of LSD-like panic and visual symptoms. |
Abstract
Risperidone, a novel antipsychotic agent, is an antagonist of postsynaptic serotonin-2 and dopamine D2 receptors. In certain individuals, the hallucinogenic drug lysergic acid diethylamide (LSD) is associated with apparently lifelong continuous visual disturbances, characterized in DSM-IV as hallucinogen-persisting perception disorder (HPPD). Because the hallucinogenic mechanism of LSD is known to act in part at postsynaptic serotonin-2 receptors, it is noteworthy that three HPPD patients treated with risperidone reported an exacerbation of LSD-like panic and visual symptoms. We conclude that HPPD may be a relative contraindication for the use of risperidone.