Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD)
Archives of Ophthalmology 1996 DOI: 10.1001/archopht.1996.01100130045007 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case series Case report Peer reviewed |
|---|---|
| Sample size | 3 |
| Population | Patients who developed persistent palinopsia after LSD ingestion |
| Intervention | LSD |
| Topics | Anxiety LSD |
| Keywords | Ingestion Afterimage Hallucinogen Plant-based medicinal research |
| Citations | 64 |
| Key findings | Persistent palinopsia can develop following LSD ingestion, and clinicians should consider past LSD use in patients with isolated palinopsia to avoid unnecessary testing. |
Abstract
We have described three patients in whom persistent palinopsia developed following ingestion of LSD. Clinicians should inquire about past LSD use in all patients who initially have seemingly spontaneous, isolated palinopsia. Recognition of this distinctive clinical syndrome associated with LSD use might avoid unnecessary anxiety and excessive diagnostic tests for patients with this disorder.
Comparable studies
Other case reports and case series on LSD for anxiety, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| LSD-Like Panic From Risperidone in Post-LSD Visual Disorder Patients with hallucinogen-persisting perception disorder (HPPD) | 1996 | Case study | n = 3 |
| Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects A 39-year-old female patient with severe, treatment-resistant depression and complex... | 2020 | Case study | n = 1 |
| LSD Overdoses: Three Case Reports Three individuals who experienced accidental LSD overdose | 2020 | Case series | n = 3 |
| BEHAVIOR THERAPY TO EXTINGUISH SPONTANEOUS RECURRENCES OF LSD EFFECTS A client experiencing spontaneous recurrences of LSD effects | 1973 | Case study | n = 1 |
| Single-dose 1cp-LSD administration for canine anxiety: a pilot study. A 13-year-old female mixed-breed dog with separation anxiety | 2024 | Case study | n = 1 |
Citations in the library
Cited by 8
- Factors associated with complex visual hallucinations during antidepressant treatment Human Psychopharmacology: Clinical and Experimental October 19, 2004
- Adverse psychiatric effects of psychedelic drugs: a systematic review of case reports. Psychological Medicine November 20, 2024
- Ocular sequelae from the illicit use of class A drugs British and Irish Orthoptic Journal 2004
- Clinical Research on Lysergic Acid Diethylamide (LSD) in Psychiatry and Neuroscience. Pharmaceuticals March 29, 2025
- RETRACTED: Long-term systemic treatment with lysergic acid diethylamide causes retinal damage in CD1 mice Human & Experimental Toxicology November 25, 2018
and 3 more in the library
Cites 7
- The Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Journal of Mental Science April 1, 1954
- Visual Phenomenology of the LSD Flashback Archives of General Psychiatry August 1, 1983
- Adverse consequences of lysergic acid diethylamide Addiction October 1, 1993
- Flashbacks: Recurrent Intrusive Images After the Use of LSD American Journal of Psychiatry October 1, 1969
- A Chronic Impairment of Colour Vision in Users of LSD The British Journal of Psychiatry May 1, 1982
and 2 more in the library