Evaluation of 1cp-LSD for Enhancing Welfare in Shelter Dogs: A Randomized Blind Trial with Ethological Intervention.
Elisa Hernández-Álvarez, Cristina Canino-Quijada, Sira Roiz, Octavio P Luzardo, Luis Alberto Henríquez-Hernández
Veterinary sciences January 19, 2026 DOI: 10.3390/vetsci13010096 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 20 |
| Population | Shelter dogs |
| Interventions | 1cp-LSD Ethological intervention |
| Dose | 10 µg |
| Duration | 3-week intervention, 3-week follow-up |
| Topics | LSD |
| Keywords | Animal behavior Animal welfare Ethological intervention Ethology Psychedelics Shelter dogs |
| Key findings | Combined low-dose 1cp-LSD and ethological intervention improved sociability, calmness, and positive emotional reactivity in shelter dogs more than either treatment alone, with effects lasting three weeks. |
Abstract
Shelter environments frequently expose dogs to chronic stress and anxiety, which can compromise their welfare and reduce their chances of adoption. Recent interest in psychedelic-assisted approaches has suggested potential therapeutic applications in veterinary behavioral medicine, although empirical evidence remains scarce. This study aimed to evaluate the combined effects of low-dose 1-cyclopropionyl lysergic acid diethylamide (1cp-LSD), a legal lysergamide prodrug of LSD in several countries, and ethological intervention (EI) on the behavior and welfare of shelter dogs. Twenty dogs were randomly assigned to four groups: pharmacological intervention, ethological intervention, combined treatment, or control. The ethological sessions were conducted by veterinary behaviorists, and pharmacological treatment consisted of 10 µg of 1cp-LSD administered orally for three weeks. Blinded evaluators assessed animals using validated anxiety and welfare scales, including a treatment expectation scale, before, during and after the intervention. Results showed that the combined condition consistently outperformed single interventions, significantly enhancing sociability, calmness, and positive emotional reactivity. Importantly, these improvements persisted for three weeks following treatment cessation, indicating sustained benefits beyond the active intervention phase. These findings provide preliminary evidence for the potential of integrating low doses of psychedelics with behavioral therapy in shelter settings. Future studies with larger cohorts and refined pharmacokinetic data are required to confirm safety, elucidate mechanisms, and optimize protocols for clinical application in veterinary practice.