Experiences of microdosing psychedelics in an attempt to support wellbeing and mental health.
Rebecca S Ryan, Alex Copello, Andrew P Fox
BMC Psychiatry March 14, 2023 DOI: 10.1186/s12888-023-04628-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Qualitative study Peer reviewed |
|---|---|
| Sample size | 13 |
| Population | People who microdose psychedelic drugs |
| Intervention | Microdosing psychedelic drugs |
| Topics | LSD Microdosing Psilocybin |
| Keywords | Mental health Wellbeing Psychedelics hallucinogens Entheogens Psychological health Emotional health Microdosing sub-perceptual dosing |
| Citations | 12 |
| Key findings | Participants approached microdosing methodically and with purpose, reporting beneficial effects on mental health, with microdosing described as a catalyst to achieving their aims. |
Abstract
Microdosing psychedelic drugs is a growing phenomenon, but little is known about the experiences surrounding this. Research broadly suggests that people may use psychedelics in an attempt to self-medicate for mental health and wellbeing. However, the precise details, rationale and meaning of such attempts remains unclear, and would benefit from clarification, using tailored experiential methods. This research therefore aimed to explore the way that users make sense of microdosing psychedelics, with a particular focus on the experience of any perceived mental health or wellbeing changes. Participants were recruited via websites and online forums. An internet text-based, semi-structured interview was conducted anonymously with 13 participants regarding their experiences of microdosing psychedelic drugs. Interpretive Phenomenological Analysis was used to analyse the transcripts. Three superordinate themes were identified through the interviews: 1) Seeking a solution: Agency and rationale; 2) Microdosers as scientists; 3) Catalysing desirable and beneficial effects. All participants approached microdosing methodically and with purpose. Participants reported that they had experienced beneficial effects of microdosing on their mental health, alongside cognitive, physical and social changes. By microdosing, participants reported that they had supported their own mental health and wellbeing, with microdosing described as a catalyst to achieving their aims in this area. This study provided additional knowledge and understanding of the experience, rationale and personal meaning of the microdosing phenomenon which can be used to inform future investigations in the areas of psychedelic use and mental health.
Comparable studies
Other qualitative studies on LSD and microdosing, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelic microdosing benefits and challenges: an empirical codebook Active microdosing community | 2019 | Mixed-methods study | |
| Qualitative content analysis of expectations in participants with depression about to begin LSD microdosing treatment: Identifying the need for psychedelic expectancy measures. Individuals with major depressive disorder (MDD) | 2025 | Qualitative study | n = 23 |
Citations in the library
Cited by 11
- Less is more? A review of psilocybin microdosing Journal of Psychopharmacology September 16, 2024
- Side effects of microdosing lysergic acid diethylamide and psilocybin: A systematic review of potential physiological and psychiatric outcomes Neuropharmacology March 7, 2025
- The effect of psychedelic microdosing on animal behavior: A review with recommendations for the field Neuroscience & Biobehavioral Reviews May 9, 2025
- Towards a dynamic processual model of psychedelic microdosing. International Journal of Drug Policy February 1, 2025
- Making sense of desperation for treatment in decisions to use psychedelics for depression and anxiety: A qualitative Subreddit study anticipating clinical challenges. General Hospital Psychiatry 2026
and 6 more in the library
Cites 18
- Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Psychopharmacology November 8, 2017
- The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future. Neuropsychopharmacology April 26, 2017
- The Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Journal of Mental Science April 1, 1954
- Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting Psychopharmacology October 24, 2018
- Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers Biological Psychiatry June 3, 2019
and 13 more in the library