Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users
Una D. Mccann, George A. Ricaurte, Domenic A. Ciraulo
Journal of Clinical Psychopharmacology October 1, 1991 DOI: 10.1097/00004714-199110000-00005 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 2 |
| Population | Persons who ingested large doses of MDMA |
| Intervention | MDMA |
| Dose | large doses |
| Topics | LSD MDMA Serotonin |
| Keywords | Hallucinogen Ingestion Serotonin syndrome Recreational use Recreational drug Dextroamphetamine Adverse effect Anesthesia Pharmacology |
| Citations | 137 |
| Key findings | Ingestion of large doses of MDMA can produce lasting adverse neuropsychiatric effects in vulnerable persons. |
Abstract
Two persons are described who demonstrated prolonged neuropsychiatric syndromes after the ingestion of large doses of (+-)-3,4-methylenedioxymethamphetamine (MDMA), a recreationally used amphetamine analog. These cases suggest that MDMA, known to be neurotoxic to serotonin neurons in several experimental animals, may also produce untoward effects in humans. In addition, they provide evidence that ingestion of large doses of MDMA can produce lasting adverse functional consequences in vulnerable persons.