Adverse consequences of lysergic acid diethylamide
Henry David Abraham, Andrew M. Aldridge
Addiction October 1, 1993 DOI: 10.1111/j.1360-0443.1993.tb02018.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD Psilocybin |
| Keywords | Hallucinogen Psychopathology Dissociative Adverse effect Clinical psychology |
| Citations | 140 |
| Key findings | LSD use is associated with panic reactions, prolonged schizoaffective psychoses, and post-hallucinogen perceptual disorder lasting up to 5 years, but not with genetic disorders. |
Abstract
Abstract The continued endemic use of hallucinogenic drugs, and of LSD in particular, raises concern regarding their short and long term adverse consequences. The epidemiology of LSD abuse is reviewed suggesting an increase in LSD use among the young as the prevalence rates for other substances continues to fall. Evidence supports the association of LSD use with panic reactions, prolonged schizoaffective psychoses and post–hallucinogen perceptual disorder, the latter being present continually for as long as 5 years. Evidence does not support claims of genetic disorders arising from hallucinogens. In light of the foregoing, current data confirm earlier findings of long lasting psychopathology arising in vulnerable individuals from the use of LSD. A hypothetical long term molecular mechanism of adverse effects is proposed.
Comparable studies
Other narrative reviews on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study of a New Schizophrenomimetic Drug—Sernyl | 1959 | Review | |
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The Pharmacology of Lysergic Acid Diethylamide: A Review | 2008 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE | 1984 | Review |
Citations in the library
Cited by 57
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies Journal of Psychopharmacology September 20, 2010
- Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives Brain Sciences March 16, 2018
- Applying an Extended Version of the Theory of Planned Behavior to Illicit Drug Use Among Students1 Journal of Applied Social Psychology August 1, 2003
- The psychopharmacology of hallucinogens. Neuropsychopharmacology April 1, 1996
and 52 more in the library
Cites 19
- Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sciences December 17, 1984
- Visual Phenomenology of the LSD Flashback Archives of General Psychiatry August 1, 1983
- Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis. Journal of Pharmacology and Experimental Therapeutics September 1, 1988
- Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses The Journal of Psychology 1955
- Flashbacks: Recurrent Intrusive Images After the Use of LSD American Journal of Psychiatry October 1, 1969
and 14 more in the library