Prolonged Adverse Reactions to LSD in Psychotic Subjects
Archives of General Psychiatry November 1, 1966 DOI: 10.1001/archpsyc.1966.01730170002002 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD Psilocybin |
| Keywords | Hallucinogen Adverse effect Depression economics Incidence geometry Psychosis Clinical psychology Pharmacology |
| Citations | 40 |
| Key findings | Prolonged adverse effects from LSD can last from one week to two years, with about 40% of cases persisting beyond that range. |
Abstract
THE INCREASED abuse of lysergic acid diethylamide (LSD) has aroused popular concern for its complications and has led the leading pharmaceutical manufacturer to withdraw its supplies from investigational use. Recent reports, especially those in the lay press, give the impression of an increasing incidence of persistent psychoses, associating the observations with the illicit use of LSD.1,2 The experimental LSD experience in medical settings is usually described as transient, limited to a few hours or at most a day. The persistence of ideational or emotional changes beyond 24 hours may be defined as "prolonged effects" and these have been reported in surprisingly few subjects.3,4The descriptions of these prolonged adverse effects generally include spontaneous recurrences of the acute LSD experience, persistent psychotic decompensations, induced depression with attempted and completed suicides, and multihabituation. The durations of these states range between one week and two years, with about 40% of the
Comparable studies
Other narrative reviews on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study of a New Schizophrenomimetic Drug—Sernyl | 1959 | Review | |
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The Pharmacology of Lysergic Acid Diethylamide: A Review | 2008 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE | 1984 | Review |
Citations in the library
Cited by 17
- Acute Effects of Drug Abuse in Schizophrenic Patients: Clinical Observations and Patients' Self-reports Schizophrenia Bulletin 1990
- The psychopharmacology of hallucinogens. Neuropsychopharmacology April 1, 1996
- On the Use and Abuse of LSD Archives of General Psychiatry March 1, 1968
- Adverse consequences of lysergic acid diethylamide Addiction October 1, 1993
- Adverse Events in Studies of Classic Psychedelics JAMA Psychiatry September 4, 2024
and 12 more in the library
Cites 7
- Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization New England Journal of Medicine December 2, 1965
- Prolonged Adverse Reactions to Lysergic Acid Diethylamide Archives of General Psychiatry May 1, 1963
- D‐Lysergic acid diethylamide (LSD): A review of its present status Clinical Pharmacology & Therapeutics March 1, 1965
- Further Studies in the Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Journal of Mental Science April 1, 1957
- Complications Associated with Lysergic Acid Diethylamide (LSD-25) JAMA July 14, 1962
and 2 more in the library