THE DISTRIBUTION AND METABOLISM OF LYSERGIC ACID DIETHYLAMIDE
Julius Axelrod, Roscoe O. Brady, Bernhard Witkop, Edward V. Evarts
Annals of the New York Academy of Sciences March 1, 1957 DOI: 10.1111/j.1749-6632.1957.tb40739.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory study Peer reviewed |
|---|---|
| Population | Various animal species |
| Intervention | LSD |
| Topics | LSD |
| Keywords | Public health Welfare Mental health Family medicine Gerontology Nursing |
| Citations | 154 |
| Key points | LSD is almost completely metabolized by the body, with considerable differences between animal species in the rate of biotransformation. |
Abstract
Late in the 1950s, Axelrod became interested in the distribution, excretion, metabolization and rate of "biotransformation" of lysergic acid diethylamide (LSD) by the body. In this first of several articles on the narcotic drug, he detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, determined that it was almost completely metabolized by the body, and found that their were considerable differences between various animal species in the rate of biotransformation of LSD.