THE DISTRIBUTION AND METABOLISM OF LYSERGIC ACID DIETHYLAMIDE
Julius Axelrod, Roscoe O. Brady, Bernhard Witkop, Edward V. Evarts
Annals of the New York Academy of Sciences March 1, 1957 DOI: 10.1111/j.1749-6632.1957.tb40739.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory study Peer reviewed |
|---|---|
| Population | Various animal species |
| Intervention | LSD |
| Topics | LSD |
| Keywords | Public health Welfare Mental health Family medicine Gerontology Nursing |
| Citations | 154 |
| Key points | LSD is almost completely metabolized by the body, with considerable differences between animal species in the rate of biotransformation. |
Abstract
Late in the 1950s, Axelrod became interested in the distribution, excretion, metabolization and rate of "biotransformation" of lysergic acid diethylamide (LSD) by the body. In this first of several articles on the narcotic drug, he detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, determined that it was almost completely metabolized by the body, and found that their were considerable differences between various animal species in the rate of biotransformation of LSD.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 24
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans The International Journal of Neuropsychopharmacology June 24, 2015
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967
- Serotonin-Sensitive Adenylate Cyclase in Neural Tissue and Its Similarity to the Serotonin Receptor: A Possible Site of Action of Lysergic Acid Diethylamide Proceedings of the National Academy of Sciences March 1, 1974
- Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide. Proceedings of the National Academy of Sciences December 1, 1977
and 19 more in the library