Development of tolerance to repeated administration of 5-methoxy-N,N-dimethyltryptamine in rats.
Michael E. Trulson, G F Keltch
European Journal of Pharmacology January 15, 1985 DOI: 10.1016/0014-2999(85)90280-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | 5-MeODMT |
| Dose | 2 mg/kg i.p., every 30 min for 4 h |
| Duration | 4-hour treatment period, with follow-up up to 4 hours after termination |
| Topics | 5-MeO-DMT DMT |
| Citations | 18 |
| Key findings | Repeated administration of 5-MeODMT produced rapid and reversible tolerance in rats, apparently due to decreased binding to serotonin receptors, contrary to earlier studies. |
Abstract
Chronic administration of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT, 2 mg/kg i.p., every 30 min for 4 h) produced a dramatic tolerance to the behavioral effects of the drug in rats. The ED50 for the syndrome-inducing effects of the drug was increased from 1.3 to 2.4 mg/kg, and the mean duration of the syndrome was decreased from 14.9 to 1.2 min after this treatment. This tolerance effect totally disappeared within 4 h following termination of drug treatment. This effect was not due to changes in the uptake of 5MeODMT into the brain, but rather appears to be due to a decrease in the binding of the drug to serotonin receptors in the central nervous system. These studies are in contrast to previous results which reported no development of tolerance to 5-MeODMT.