Ontogeny of the behavioral effects of lysergic acid diethylamide in cats
Michael E. Trulson, Gailyn A. Howell
Developmental Psychobiology July 1, 1984 DOI: 10.1002/dev.420170402 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Kittens between 4 and 112 days postpartum |
| Intervention | Lysergic acid diethylamide (LSD) |
| Duration | 112 days postpartum |
| Topics | LSD |
| Citations | 5 |
| Key findings | LSD-induced behaviors in kittens emerge around 21 days of age, reach adult levels by 35–40 days, and young kittens are resistant to tolerance development. |
Abstract
AbstractThe ontogeny of the behavioral effects of lysergic acid diethylamide (LSD) was examined in cats between the ages of 4 and 112 days postpartum. The kittens showed little LSD‐induced behavioral change prior to 14 days of age. By the age of 21 days, however, the kittens exhibited many of the behavioral signs characteristic of LSD‐induced behaviors in adult cats. These behaviors include limbflicking, abortive grooming, head‐shakes, grooming, and investigatory responses. In general, these behaviors began at a low frequency of occurrence, then increased rapidly with advancing age, reaching adult values by approximately 35–40 days of age, and remained relatively constant through 112 days postpartum. The time course for the behavioral effects following an acute injection of LSD showed the adult pattern, i.e., persisting for approximately 8 hr post‐injection, from their earliest appearance during ontogeny. Young kittens (21–42 days of age) were resistant to the development of tolerance following repeated administration of the drug. LSD was capable of eliciting certain behaviors, such as head‐shakes and grooming, well in advance of the age at which they normally appear spontaneously. This indicates that the neuronal and musculature substrata are developed for the performance of these behaviors long before the kitten naturally employs them.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 2
Cites 8
- Studies on Lysergic Acid Diethylamide (LSD-25) A M A Archives of Neurology & Psychiatry November 1, 1956
- CLINICAL REACTIONS AND TOLERANCE TO LSD IN CHRONIC SCHIZOPHRENIA The Journal of Nervous and Mental Disease September 1, 1955
- Interactions between lysergic acid diethylamide and dopamine-sensitive adenylate cyclase systems in rat brain Brain Research August 1, 1975
- Some Effects of Bufotenine and Lysergic Acid Diethylamide on the Monkey Archives of Neurology And Psychiatry 1956
- Effects of LSD-25 and Amphetamine on a Running Response in the Rat Archives of General Psychiatry 1960
and 3 more in the library