Analeptic Action of Lysergic Acid Diethylamide (LSD-25) Against Pentobarbital
Archives of Neurology And Psychiatry June 1, 1958 DOI: 10.1001/archneurpsyc.1958.02340060109015 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 140 |
| Population | Cats |
| Interventions | LSD-25 pentobarbital |
| Topics | LSD |
| Keywords | Pentobarbital Cats Analeptic Pharmacology Chlorpromazine Anesthetic Reticular formation Anesthesia Central nervous system Toxicology |
| Citations | 9 |
| Key findings | LSD-25 safely and effectively reversed respiratory and central nervous system depression induced in cats by lethal doses of pentobarbital. |
Abstract
Adventitious findings in this laboratory indicate that lysergic acid diethylamide (LSD-25) protects cats against the toxic effects of large doses of pentobarbital. One hundred forty cats have survived inordinate amounts of pentobarbital at the termination of experiments in which LSD-25 solution was given systemically. Gastaut,13Bradley,3,4and others6,8,14,18provide electrophysiological evidence that LSD-25 antagonizes the action of anesthetic doses of barbiturates. In these studies the actions of both drugs on the frontal cortex and on the reticular formation were investigated. There appear to be no reports, however, of the extent to which LSD might inhibit or reverse lethal effects of larger doses of barbiturates. It seemed worth while, therefore, to investigate in greater detail this protective property of LSD. Under the conditions of the present studies, LSD-25 safely and effectively reversed respiratory and central nervous system depression induced in cats by lethal doses of pentobarbital. What is