JAMA Internal Medicine
June 29, 2026
Natalia E. Morone, Keturah R Faurot, Janice M Weinberg et al.
Importance: Back pain is among the most common, disabling, and costly conditions managed in primary care in the US, but current treatment options often do not provide adequate relief. Mindfulness-based interventions have demonstrated effectiveness in individuals with chronic low back pain (CLBP); however, mindfulness remains underused in part because it is not integrated into most outpatient...
JAMA Internal Medicine
May 1, 2026
Devan Kansagara, Garth E Terry, Chelsea K Ayers et al.
Cannabis use is common among those with mental health conditions, and many people report using cannabis to manage mental health symptoms. It is important for clinicians to understand the lack of clear benefits of cannabis for mental health conditions and the potential for substantial adverse effects. Overall, the potential benefits of cannabis for mental health conditions remain poorly studied....
JAMA Internal Medicine
August 19, 2024
Diana J. Burgess, Collin M Calvert, E. H. Hagel Campbell et al.
Importance Although mindfulness-based interventions (MBIs) are evidence-based treatments for chronic pain and comorbid conditions, implementing them at scale poses many challenges, such as the need for dedicated space and trained instructors. Objective To examine group and self-paced, scalable, telehealth MBIs, for veterans with chronic pain, compared to usual care. Design, Setting, and...
JAMA Internal Medicine
July 1, 2024
Christopher E Cox, John A Gallis, Maren K Olsen et al.
22 citations
Although psychological distress is common among survivors of critical illness, there are few tailored therapies. To determine the optimal method for delivering a mindfulness intervention via a mobile app for critical illness survivors. This randomized clinical trial used a 2 × 2 × 2 factorial design and was conducted at 3 sites among survivors of critical illness with elevated postdischarge...
JAMA Internal Medicine
February 28, 2022
E. Garland, Adam W. Hanley, Yoshio Nakamura et al.
Key Points Question Does a mindfulness-based intervention reduce comorbid chronic pain and opioid misuse in the primary care setting more than supportive psychotherapy? Findings In this randomized clinical trial that included 250 adults with both chronic pain and opioid misuse, 45.0% of participants receiving Mindfulness-Oriented Recovery Enhancement (MORE) were no longer misusing opioids after...
JAMA Internal Medicine
March 1, 2016
Natalia E. Morone, Carol M. Greco, Charity G Moore et al.
Importance: Treatment of chronic low back pain (LBP) in older adults is limited by the adverse effects of analgesics. Effective nonpharmacologic treatment options are needed. Objective: To determine the effectiveness of a mind-body program at increasing function and reducing pain in older adults with chronic LBP. Design, setting, and participants: This single-blind, randomized clinical trial...
JAMA Internal Medicine
February 16, 2015
David S. Black, Gillian A. O’Reilly, Richard Olmstead et al.
485 citations
IMPORTANCE: Sleep disturbances are most prevalent among older adults and often go untreated. Treatment options for sleep disturbances remain limited, and there is a need for community-accessible programs that can improve sleep. OBJECTIVE: To determine the efficacy of a mind-body medicine intervention, called mindfulness meditation, to promote sleep quality in older adults with moderate sleep...
JAMA Internal Medicine
January 6, 2014
Madhav Goyal, Sonal Singh, Erica Sibinga et al.
2,323 citations
IMPORTANCE: Many people meditate to reduce psychological stress and stress-related health problems. To counsel people appropriately, clinicians need to know what the evidence says about the health benefits of meditation. OBJECTIVE: To determine the efficacy of meditation programs in improving stress-related outcomes (anxiety, depression, stress/distress, positive mood, mental health-related...