Esketamine-based treatment, depression-specific metacognitive training, and their combination in treatment-resistant depression: 6-month trajectories of depressive symptoms and rumination in a multicenter observational study.
Eur Arch Psychiatry Clin Neurosci August 29, 2026 DOI: 10.1007/s00406-026-02361-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Patients with treatment-resistant depression |
| Interventions | Esketamine Depression-specific metacognitive training |
| Duration | 6-month follow-up |
| Topics | Depression Esketamine |
| Key findings | Depressive symptoms and rumination improved over six months across all treatment groups, with the combination of esketamine and metacognitive training showing the largest reductions, suggesting an additive benefit of the combined approach. |
Abstract
Esketamine-based treatment, depression-specific metacognitive training, and their combination in treatment-resistant depression: 6-month trajectories of depressive symptoms and rumination in a multicenter observational study.