Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
September 9, 2026
Philip N Tubiolo, Yash Patel, Alexandria Trepiccione et al.
Few human imaging studies investigate psychotogenic models during late adolescence. The "triple network" model posits that hallucinations are related to abnormal connectivity among the frontoparietal (FPN), default mode (DMN) and salience/cingulo-opercular (CON) networks but has not been tested during this age range, and is not well integrated with the hyper-dopaminergic model of psychosis. We...
Nature Reviews Neuroscience
December 2019
Guillermo Horga, Anissa Abi‐dargham
Perceptual disturbances in psychosis, such as auditory verbal hallucinations, are associated with increased baseline activity in the associative auditory cortex and increased dopamine transmission in the associative striatum. Perceptual disturbances are also associated with perceptual biases that suggest increased reliance on prior expectations. We review theoretical models of perceptual...
European Psychiatry
July 17, 2016
Andreas Heinz, Martin Voss, Stephen M. Lawrie et al.
84 citations
BACKGROUND: First rank symptoms (FRS) of schizophrenia have been used for decades for diagnostic purposes. In the new version of the DSM-5, the American Psychiatric Association (APA) has abolished any further reference to FRS of schizophrenia and treats them like any other "criterion A" symptom (e.g. any kind of hallucination or delusion) with regard to their diagnostic implication. The ICD-10...
Biological Psychiatry
April 15, 2012
Nina B L Urban, Mark Slifstein, Judy L. Thompson et al.
Low striatal dopamine 2/3 receptor (D(2/3)) availability and low ventrostriatal dopamine (DA) release have been observed in alcoholism and cocaine and heroin dependence. Less is known about the dopaminergic system in cannabis dependence. We assessed D(2/3) availability and DA release in abstinent cannabis users compared with control subjects and explored relationships to cannabis use history...
Archives of General Psychiatry
September 1, 2005
John H. Krystal, Edward Perry, Ralitza Gueorguieva et al.
323 citations
BACKGROUND: In healthy individuals, ketamine hydrochloride and amphetamine sulfate produce cognitive, behavioral, and subjective effects resembling endogenous psychoses. Studying the comparative and interactive effects of these agents may provide insights into the roles of the glutamate and monoamine systems in psychosis and cognition. OBJECTIVES: To directly compare the effects of ketamine and...
Biological Psychiatry
October 1, 2000
Lawrence S. Kegeles, Anissa Abi‐dargham, Y. Zea‐Ponce et al.
BACKGROUND Recent brain imaging studies have indicated that schizophrenia is associated with increased amphetamine-induced dopamine release in the striatum. It has long been hypothesized that dysregulation of subcortical dopamine systems in schizophrenia might result from a failure of the prefrontal cortex (PFC) to adequately control subcortical dopaminergic function. The activity of midbrain...
Biological Psychiatry
January 15, 2000
J. Krystal, A. Bennett, D. Abi‐Saab et al.
BACKGROUND The demands of the Wisconsin Card Sorting Test (WCST) change with experience. This report contains two studies designed to examine N-methyl-D-aspartate (NMDA) receptor contributions to the executive components of WCST performance. These aspects of WCST performance figure more prominently in the initial completion of this task than in subsequent task repetitions in healthy...