Effects of LSD-25 on Relatives of Schizophrenic Patients
G Anastasopoulos, Harry Photiades
Journal of Mental Science 1962 DOI: 10.1192/bjp.108.452.95 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Schizophrenic patients and normal experimental subjects |
| Intervention | LSD-25 |
| Topics | LSD |
| Keywords | Psychopathology Heredity Psychosis Clinical psychology Schizophrenia object-oriented programming Paranoid schizophrenia Genetics |
| Citations | 41 |
| Key findings | LSD-25 increases psychopathological phenomena in schizophrenic patients and can induce paranoid symptoms in some normal subjects, but the role of heredity in the latter is unknown. |
Abstract
Schizophrenic patients given LSD-25 show an increase of psychopathological phenomena and a regression to the prime stage of their psychosis, the manifestations of which seem to be more directly related to the life history of the patients. ∗ It has also been observed that some “normal” experimental subjects show various paranoid symptoms with the same drug, but whether these are in any way determined by heredity is not known.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 18
- Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms Pharmacological Reviews December 16, 2020
- LSD Psychosis or LSD-Induced Schizophrenia? Archives of General Psychiatry August 1, 1983
- d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology International Journal of Molecular Sciences November 23, 2016
- LSD, madness and healing: Mystical experiences as possible link between psychosis model and therapy model. Psychological Medicine March 1, 2023
- Psychiatric risks for worsened mental health after psychedelic use. Journal of Psychopharmacology March 4, 2024
and 13 more in the library