Even as prescription opioid dispensing rates have begun to decrease, the use of illicit opioids such as heroin and fentanyl has increased. Thus, the end of the opioid epidemic is not in sight, and treating patients that are addicted to opioids remains of utmost importance. Currently, the primary pharmacotherapies used to treat opioid addiction over the long term are the opioid antagonist...
3,4,5-Trimethoxyphenyl-β-aminopropane (TMA) is structurally related to both amphetamine and mescaline, as is shown in Figure 1. Because of this structural relationship of TMA and amphetamine, methedrine, and mescaline, one could anticipate a clinical response to the compound which would represent certain phenomena characteristic of each of these drugs. This presented an intriguing problem as to...