Alleviation of the Psychological Effects of LSD in Man by 5-Hydroxytryptophan
J. C. Brengelmann, C. M. B. Pare, M. Sandler
Journal of Mental Science October 1, 1958 DOI: 10.1192/bjp.104.437.1237 (opens in new tab) via OpenAlex
Study at a glance
AI-extracted from the abstract| Characteristics | Placebo-controlled experiment Peer reviewed |
|---|---|
| Interventions | 5-hydroxytryptophan LSD |
| Topics | LSD Psilocybin Serotonin |
| Keywords | 5-hydroxytryptophan Hallucinogen Placebo |
| Citations | 31 |
| Key findings | 5-hydroxytryptophan administered prior to LSD reduces the psychological effects of LSD. |
Abstract
In the investigation described, the hypothesis was tested that 5-hydroxytryptamine (5HT) acts to reduce the psychological effects of lysergic acid diethylamide (LSD). The method was to inject 5-hydroxytryptophan (5HTP) prior to LSD and to compare the results of psychological tests performed after these injections. Placebo controls were used.