Alleviation of the Psychological Effects of LSD in Man by 5-Hydroxytryptophan
J. C. Brengelmann, C. M. B. Pare, M. Sandler
Journal of Mental Science October 1, 1958 DOI: 10.1192/bjp.104.437.1237 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Placebo-controlled experiment Peer reviewed |
|---|---|
| Interventions | 5-hydroxytryptophan LSD |
| Topics | LSD Psilocybin Serotonin |
| Keywords | 5-hydroxytryptophan Hallucinogen Placebo Clinical psychology |
| Citations | 31 |
| Key findings | 5-hydroxytryptophan administered prior to LSD reduces the psychological effects of LSD. |
Abstract
In the investigation described, the hypothesis was tested that 5-hydroxytryptamine (5HT) acts to reduce the psychological effects of lysergic acid diethylamide (LSD). The method was to inject 5-hydroxytryptophan (5HTP) prior to LSD and to compare the results of psychological tests performed after these injections. Placebo controls were used.
Comparable studies
Other randomized controlled trials on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases Patients with anxiety associated with life-threatening diseases | 2014 | Randomized controlled trial | n = 12 |
| Dose-Response Study of N,N-Dimethyltryptamine in Humans Experienced hallucinogen users | 1994 | Double-blind, saline placebo-controlled, randomized study | n = 12 |
| Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Healthy subjects (8 women, 8 men) | 2014 | Double-blind, randomized, placebo-controlled, crossover study | n = 16 |
| Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor Healthy human participants | 2018 | Double-blind, randomized, counterbalanced, cross-over study | n = 24 |
| LSD-induced entropic brain activity predicts subsequent personality change. Healthy adults | 2016 | Balanced-order, placebo-controlled study | n = 19 |
Citations in the library
Cited by 3
- Dose-Response Study of N,N-Dimethyltryptamine in Humans Archives of General Psychiatry February 1, 1994
- Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5‐HT in the UK British Journal of Pharmacology June 2, 2008
- Effects of LSD-25 on Tests of Personality Journal of Mental Science October 1, 1958