Research published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (page 2)

Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging February 1, 2024 Friederike Holze, Nirmal Singh, Matthias E. Liechti et al. 50 citations

Psychedelic compounds, including psilocybin, LSD (lysergic acid diethylamide), DMT (N,N -dimethyltryptamine), and 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), all of which are serotonin 2A receptor agonists, are being investigated as potential treatments. This review aims to summarize the current clinical research on these 4 compounds and mescaline to guide future research. Their mechanism(s)...

DOI: 10.1016/j.bpsc.2024.01.007 Mescaline Psilocybin Lysergic acid diethylamide Serotonergic +4

Striatal Iron Deposition in Recreational MDMA (Ecstasy) Users.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging September 2023 Rebecca C Coray, Jatta Berberat, Josua Zimmermann et al.

The common club drug MDMA (also known as ecstasy) enhances mood, sensory perception, energy, sociability, and euphoria. While MDMA has been shown to produce neurotoxicity in animal models, research on its potential neurotoxic effects in humans is inconclusive and has focused primarily on the serotonin system. We investigated 34 regular, largely pure MDMA users for signs of premature...

DOI: 10.1016/j.bpsc.2023.02.005 Full text Addiction Empathogens Imaging Iron load +4

Comparing Neural Correlates of Consciousness: From Psychedelics to Hypnosis and Meditation

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging July 17, 2023 Flora Moujaes, Nathalie M. Rieser, Christophe Phillips et al. 19 citations

BACKGROUND: Pharmacological and nonpharmacological methods of inducing altered states of consciousness (ASCs) are becoming increasingly relevant in the treatment of psychiatric disorders. While comparisons between them are often drawn, to date no study has directly compared their neural correlates. METHODS: To address this knowledge gap, we directly compared 2 pharmacological methods...

DOI: 10.1016/j.bpsc.2023.07.003 Psilocybin Meditation Default mode network Hypnosis +6

Differential Expression of Anomalous Self-Experiences in Spontaneous Speech in Clinical High-Risk and Early-Course Psychosis Quantified by Natural Language Processing.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging July 5, 2023 Agrima Srivastava, Alexandria Selloni, Zarina R Bilgrami et al.

Background: Basic self-disturbance, or anomalous self-experiences (ASEs), is a core feature of the schizophrenia spectrum. We propose a novel method of natural language processing to quantify ASEs in spoken language by direct comparison to an inventory of self-disturbance, the Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE). We hypothesized that there would be increased...

DOI: 10.1016/j.bpsc.2023.06.007 Full text Humans Speech Psychotic disorders Schizophrenia +5

Spatial Correspondence of LSD-Induced Variations on Brain Functioning at Rest With Serotonin Receptor Expression.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging July 1, 2023 Stefano Delli Pizzi, Piero Chiacchiaretta, Carlo Sestieri et al. 18 citations

Lysergic acid diethylamide (LSD) is an atypical psychedelic compound that exerts its effects through pleiotropic actions, mainly involving 1A/2A serotoninergic (5-HT) receptor subtypes. However, the mechanisms by which LSD promotes a reorganization of the brain's functional activity and connectivity are still partially unknown. Our study analyzed resting-state functional magnetic resonance...

DOI: 10.1016/j.bpsc.2023.03.009 Full text 5-ht2a Hallucinations Psychedelics LSD Acid +4

Neuroimaging-Derived Biomarkers of the Antidepressant Effects of Ketamine

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging November 25, 2022 Artemis Zavaliangos-Petropulu, Noor B. Al-Sharif, Brandon Taraku et al. 27 citations

Major depressive disorder is a highly prevalent psychiatric disorder. Despite an extensive range of treatment options, about a third of patients still struggle to respond to available therapies. In the last 20 years, ketamine has gained considerable attention in the psychiatric field as a promising treatment of depression, particularly in patients who are treatment resistant or at high risk for...

DOI: 10.1016/j.bpsc.2022.11.005 Ketamine Default mode network Major depressive disorder Neuroplasticity +10

Interoception Underlies Therapeutic Effects of Mindfulness Meditation for Posttraumatic Stress Disorder: A Randomized Clinical Trial.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging August 1, 2022 Seung Suk Kang, Scott R Sponheim, Kelvin O Lim

Mindfulness-based interventions have proven efficacy in treating posttraumatic stress disorder (PTSD), but the neurobiological mechanism underlying the therapeutic effects is unknown. As mindfulness meditation cultivates attention to the present moment and bodily sensations, neural functions related to interoception (i.e., central processes of bodily signals) might be such a mechanism. We...

DOI: 10.1016/j.bpsc.2021.10.005 Full text Meditation Mindfulness EEG Interoception +2

Characterizing Thalamocortical (Dys)connectivity Following D-Amphetamine, LSD, and MDMA Administration

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging April 29, 2022 Mihai Avram, Felix Müller, Helena Rogg et al. 43 citations

Psychedelics, empathogens, and psychostimulants evoke thalamocortical hyperconnectivity with sensorimotor areas, akin to findings in patients with psychotic disorders.

DOI: 10.1016/j.bpsc.2022.04.003 MDMA Amphetamine Hallucinogen Pharmacology

Mnemnonic Discrimination Deficits in First Episode Psychosis and a Ketamine Model Suggests Dentate Gyrus Pathology Linked to NMDA-Receptor Hypofunction

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging October 1, 2021 N. Kraguljac, Matthew S. Carle, M. Frölich et al.

Background: Converging evidence from neuroimaging and post-mortem studies suggests that hippocampal subfields are differentially affected in schizophrenia. Recent studies report dentate gyrus dysfunction in chronic schizophrenia, but the underlying mechanisms remain to be elucidated. Here we sought examine if this deficit is already present in first episode psychosis, and if...

DOI: 10.1016/j.bpsc.2021.09.008 Full text

Review of the Endocannabinoid System

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging August 1, 2020 Hui-Chen Lu, Ken Mackie

The endocannabinoid system (ECS) is a widespread neuromodulatory network involved both in the developing CNS as well as playing a major role in tuning many cognitive and physiological processes. The ECS is composed of endogenous cannabinoids, cannabinoid receptors and the enzymes responsible for the synthesis and degradation of endocannabinoids. In addition to its endogenous roles, cannabinoid...

DOI: 10.1016/j.bpsc.2020.07.016 Full text

Δ9-Tetrahydrocannabinol During Encoding Impairs Perceptual Details yet Spares Context Effects on Episodic Memory.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2020 Manoj K. Doss, Jessica Weafer, David A Gallo et al.

With the growing acceptance of cannabis use, it is crucial to understand the drug's effects on episodic memory accuracy and distortion. We investigated the impact of the administration of Δ9-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, on a context-based memory illusion. In a double-blind, placebo-controlled, within-subjects design, healthy infrequent cannabis...

DOI: 10.1016/j.bpsc.2019.08.007 Full text Cannabis THC Context reinstatement Episodic memory +2

Ketamine Enhances Visual Sensory Evoked Potential Long-term Potentiation in Patients With Major Depressive Disorder.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging January 2020 Rachael Sumner, Rebecca McMillan, Meg J. Spriggs et al.

The rapid-acting clinical effects of ketamine as a novel treatment for depression along with its complex pharmacology have made it a growing research area. One of the key mechanistic hypotheses for how ketamine works to alleviate depression is by enhancing long-term potentiation (LTP)-mediated neural plasticity. The objective of this study was to investigate the plasticity hypothesis in 30...

DOI: 10.1016/j.bpsc.2019.07.002 Full text Depression Ketamine Dynamic causal modeling Electroencephelography +2

Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging December 20, 2019 Anya K. Bershad, Katrin H. Preller, Royce Lee et al. 95 citations

BackgroundThe practice of "microdosing," or the use of repeated, very low doses of lysergic acid diethylamide (LSD) to improve mood or cognition, has received considerable public attention, but empirical studies are lacking. Controlled studies are needed to investigate both the therapeutic potential and the neurobiological underpinnings of this pharmacologic treatment.MethodsThe present study...

DOI: 10.1016/j.bpsc.2019.12.007 Full text LSD Neuroplasticity Microdosing Psychedelics +16

Selective Prefrontal Disinhibition in a Roving Auditory Oddball Paradigm Under N-Methyl-D-Aspartate Receptor Blockade.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging February 2019 Richard E Rosch, Ryszard Auksztulewicz, Pui Duen Leung et al.

Disturbances in N-methyl-D-aspartate receptors (NMDARs)-as implicated in patients with schizophrenia-can cause regionally specific electrophysiological effects. Both animal models of NMDAR blockade and clinical studies in patients with schizophrenia have suggested that behavioral phenotypes are associated with reduction in inhibition within the frontal cortex. Here we investigate event-related...

DOI: 10.1016/j.bpsc.2018.07.003 Full text Ketamine Dynamic causal modeling EEG Erp +3

Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging May 2018 Anita D Barber, Martin A Lindquist, Pamela DeRosse et al.

Psychotic-like experiences (PLEs) are associated with lower social and occupational functioning, and lower executive function. Emerging evidence also suggests that PLEs reflect neural dysfunction resembling that of psychotic disorders. The present study examined dynamic connectivity related to a measure of PLEs derived from the Achenbach Adult Self-Report, in an otherwise-healthy sample of...

DOI: 10.1016/j.bpsc.2017.09.008 Full text Default mode network Dynamic connectivity Executive function Psychosis +1

Subcortical Local Functional Hyperconnectivity in Cannabis Dependence

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging November 23, 2017 Peter Manza, Dardo G. Tomasi, Nora D. Volkow 61 citations

BACKGROUND: Cannabis abuse (CA) has been associated with psychopathology, including negative emotionality and higher risk of psychosis, particularly with early age of initiation. However, the mechanisms underlying this association are poorly understood. Because aberrant dopamine signaling is implicated in cannabis-associated psychopathology, we hypothesized that regular CA would be associated...

DOI: 10.1016/j.bpsc.2017.11.004

Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging October 2017 Chadi G. Abdallah, Christopher L. Averill, Ramiro Salas et al.

Prefrontal global brain connectivity with global signal regression (GBCr) was proposed as a robust biomarker of depression, and was associated with ketamine's mechanism of action. Here, we investigated prefrontal GBCr in treatment-resistant depression (TRD) at baseline and following treatment. Then, we conducted a set of pharmacological challenges in healthy subjects to investigate the...

DOI: 10.1016/j.bpsc.2017.04.006 Full text Ketamine Treatment resistant depression Functional MRI Global brain connectivity +2

Mnemonic Discrimination Deficits in First Episode Psychosis and a Ketamine Model Suggests Dentate Gyrus Pathology Linked to NMDA-Receptor Hypofunction

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging February 28, 2017 N. Kraguljac, Matthew S. Carle, M. Frölich et al. Retracted

Background Converging evidence from neuroimaging and post-mortem studies suggests that hippocampal subfields are differentially affected in schizophrenia. Recent studies report dentate gyrus dysfunction in chronic schizophrenia, but the underlying mechanisms remain to be elucidated. Here we sought examine if this deficit is already present in first episode psychosis, and if N-methyl-d-aspartate...

DOI: 10.1016/j.bpsc.2017.02.005 Full text

Hallucinations as top-down effects on perception.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging September 1, 2016 Albert R. Powers, Megan S Kelley, Philip R. Corlett

The problem of whether and how information is integrated across hierarchical brain networks embodies a fundamental tension in contemporary cognitive neuroscience, and by extension, cognitive neuropsychiatry. Indeed, the penetrability of perceptual processes in a 'top-down' manner by higher-level cognition-a natural extension of hierarchical models of perception-may contradict a strictly modular...

DOI: 10.1016/j.bpsc.2016.04.003 Full text Connectivity Neuropsychology Hallucinations Psychosis +3

Altered Neural Processing to Social Exclusion in Young Adult Marijuana Users.

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging March 1, 2016 Jodi M Gilman, Max T Curran, Vanessa Calderon et al.

Previous studies have reported that peer groups are one of the most important predictors of adolescent and young adult marijuana use, and yet the neural correlates of social processing in marijuana users have not yet been studied. In the current study, marijuana-using young adults (n = 20) and non-using controls (n = 22) participated in a neuroimaging social exclusion task called Cyberball, a...

DOI: 10.1016/j.bpsc.2015.11.002 Full text Cannabis Marijuana Acc Social influence +4

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