Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences.
Anita D Barber, Martin A Lindquist, Pamela DeRosse, Katherine H. Karlsgodt
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging May 2018 DOI: 10.1016/j.bpsc.2017.09.008 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 229 |
| Population | Otherwise-healthy adults from the Human Connectome Project, comprising 76 PLE-endorsing and 153 control participants |
| Measures | Achenbach Adult Self-Report |
| Topics | Default mode network |
| Keywords | Dynamic connectivity Executive function Psychosis Psychotic experiences |
| Key findings | Adults endorsing psychotic-like experiences spent more time in a dynamic connectivity state characterized by visual hyperconnectivity and default mode network hypoconnectivity, and less time in a state with robust within-network connectivity and strong default mode anticorrelations, compared with controls. Within the PLE group, worse executive function was associated with more time in and transitions into the visual-hyperconnectivity state and less time in a third state. |
Abstract
Psychotic-like experiences (PLEs) are associated with lower social and occupational functioning, and lower executive function. Emerging evidence also suggests that PLEs reflect neural dysfunction resembling that of psychotic disorders. The present study examined dynamic connectivity related to a measure of PLEs derived from the Achenbach Adult Self-Report, in an otherwise-healthy sample of adults from the Human Connectome Project. A total of 76 PLE-endorsing and 153 control participants were included in the final sample. To characterize network dysfunction, dynamic connectivity states were examined across large-scale resting-state networks using dynamic conditional correlation and k-means clustering. Three dynamic states were identified. The PLE-endorsing group spent more time than the control group in state 1, a state reflecting hyperconnectivity within visual regions and hypoconnectivity within the default mode network, and less time in state 2, a state characterized by robust within-network connectivity for all networks and strong default mode network anticorrelations. Within the PLE-endorsing group, worse executive function was associated with more time spent in and more transitions into state 1 and less time spent in and fewer transitions into state 3. PLEs are associated with altered large-scale brain dynamics, which tip the system away from spending more time in states reflecting more "typical" connectivity patterns toward more time in states reflecting visual hyperconnectivity and default mode hypoconnectivity.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |
Citations in the library
Cited by 3
- Default mode network functional connectivity negatively associated with trait openness to experience Social Cognitive and Affective Neuroscience April 23, 2021
- Dynamic brain states underlying advanced concentrative absorption meditation: A 7-T fMRI-intensive case study. Network Neuroscience 2025
- The Salience of Psychotic Experiences: Neural Correlates in the General Population. Schizophrenia Bulletin July 1, 2026