Molecular Neurobiology
November 1, 2024
Adam M Lee, Paul Thuras, Joshua Baller et al.
9 citations
Meditation-based interventions are novel and effective non-pharmacologic treatments for veterans with PTSD. We examined relationships between treatment response, early life trauma exposure, DNA polymorphisms, and methylation in the serotonin transporter (SLC6A4) and FK506-binding protein 5 (FKBP5) genes. DNA samples and clinical outcomes were examined in 72 veterans with PTSD who received...
Mindfulness
October 1, 2022
Itamar Shapira, Joshua Richman, Thaddeus W W Pace et al.
This study evaluates the effects of treatment with mindfulness-based stress reduction (MBSR) compared to the active control, present-centered group therapy (PCGT), on morning plasma cortisol, interleukin-6 (IL-6), and C-reactive protein (CRP) in veterans diagnosed with post-traumatic stress disorder (PTSD). In a post hoc exploratory analysis, we pooled biomarkers and clinical outcomes of...
Biological psychiatry. Cognitive neuroscience and neuroimaging
August 1, 2022
Seung Suk Kang, Scott R Sponheim, Kelvin O Lim
Mindfulness-based interventions have proven efficacy in treating posttraumatic stress disorder (PTSD), but the neurobiological mechanism underlying the therapeutic effects is unknown. As mindfulness meditation cultivates attention to the present moment and bodily sensations, neural functions related to interoception (i.e., central processes of bodily signals) might be such a mechanism. We...
arXiv Preprint Archive
October 12, 2020
Seung Suk Kang, Scott R Sponheim, Kelvin O Lim et al.
Mindfulness-based interventions have proven its efficacy in treating post-traumatic stress disorder (PTSD), but the underlying neurobiological mechanism is unknown. To determine the neurobiological mechanism of action of mindfulness-based stress reduction (MBSR) treating PTSD, we conducted a randomized clinical trial (RCT) in which 98 veterans with PTSD were randomly assigned to receive MBSR...
Translational Psychiatry
June 26, 2020
Paulo R Shiroma, Paul Thuras, J. Wels et al.
112 citations
The strategy of repeated ketamine in open-label and saline-control studies of treatment-resistant depression suggested greater antidepressant response beyond a single ketamine. However, consensus guideline stated the lack of evidence to support frequent ketamine administration. We compared the efficacy and safety of single vs. six repeated ketamine using midazolam as active placebo. Subjects...
Stress
2020
Bonnie Klimes-Dougan, Li Shen Chong, Ali Samikoglu et al.
Transcendental meditation (TM) is effective in alleviating stress and anxiety and promoting well-being. While the underlying biological mechanisms of TM are not yet fully explored, the hypothalamic-pituitary-adrenal (HPA) axis represents an index providing important clues embodying the stress system cascade. In this pilot study, young adults were randomly assigned to TM training followed by 8...
Psychological trauma : theory, research, practice and policy
November 1, 2018
Seung Suk Kang, Christopher R Erbes, Greg J Lamberty et al.
Transcendental Meditation (TM) is a mental technique using a mantra to facilitate meditation. TM has a potential for treating symptoms of posttraumatic stress disorder (PTSD), but its clinical efficacy remains to be clarified. This pilot study evaluated the acceptability, preliminary effectiveness, and neurophysiology of TM for veterans with PTSD. Twenty-nine veterans (20.7% female) were...
Frontiers in Psychiatry
2018
Jeffrey R Bishop, Adam M Lee, Lauren J Mills et al.
Mindfulness Based Stress Reduction (MBSR) is an effective non-pharmacologic treatment for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD disease risk and pathophysiology, but how these factors influence treatment response is unclear. Serotonin signaling and hypothalamic-pituitary-adrenal (HPA) axis functioning may be perturbed in PTSD and are molecular...