Expert Opinion on Drug Discovery
July 4, 2026
Christopher D. Verrico, Lynnette A. Averill, Cameron J Moore et al.
INTRODUCTION: Ibogaine is a naturally occurring indole alkaloid with suggested therapeutic potential across substance use disorders, trauma-related conditions, mood disorders, and suicidality. However, its clinical translation has been hindered by safety concerns, regulatory barriers, and uncertainty regarding its complex pharmacology. Recent interest has surged in developing ibogaine analogs...
World Journal of Advanced Research and Reviews
November 30, 2022
Calixto Machado, Andrew B. Newberg, Yanín Machado et al.
This study compares the critical neural correlates of two altered states of consciousness: near-death experience (NDE) and spiritual contemplative experience (SCE), a.k.a. mystical experience. For Centuries NDE and SCE have been reported by all faiths, including Abrahamic religious contemplatives: Christian mystics, Muslim Sufis, and Jewish Kabbalists. Their anecdotal reports show that both NDE...
World Journal of Advanced Research and Reviews
November 11, 2022
Calixto Machado, Andrew B. Newberg, Yanín Machado et al.
We recently recorded, processed, and published brain activity by quantitative electroencephalography (QEEG) and quantitative electroencephalography (QEEGt), comparing separate subjects remembering their near-death experience (NDE) and mystical experience. Our studies refer to a mystical experience as a spiritual contemplative experience (SCE). We found neural and Greyson Scale (GS) correlations...
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
October 2017
Chadi G. Abdallah, Christopher L. Averill, Ramiro Salas et al.
Prefrontal global brain connectivity with global signal regression (GBCr) was proposed as a robust biomarker of depression, and was associated with ketamine's mechanism of action. Here, we investigated prefrontal GBCr in treatment-resistant depression (TRD) at baseline and following treatment. Then, we conducted a set of pharmacological challenges in healthy subjects to investigate the...