This paper reflects on potential contributions from anthropology to the field of “psychedelic science.” Although the discipline’s beginnings went hand in hand with colonialism, it has made significant contributions to the understanding of Indigenous knowledge systems. Furthermore, recent calls to decolonize our theoretical frameworks and methodology, notably the “ontological turn,” open up the...
Although Native American communities are unique in their beliefs, traditions, and languages, there are some fundamental common belief systems shared by most Native American cultures. Therapists and other practitioners engaging in a healing relationship with Native Peoples should be aware of these fundamental aspects of the Native American culture. This includes trust/respect, confidentiality...
A series of illustrations in a 15th century Timurid manuscript record the mi’raj, the ascent through the seven heavens by Mohammed, the Prophet of Islam. Several of the illustrations depict Burāq, the fabulous creature by means of which Mohammed achieves his ascent, with distinctive features of the Amanita muscaria mushroom. A. muscaria or “fly agaric” is a psychoactive mushroom used by...
Background and aims Set and setting function both as a concept that guides research and practice with psychedelic drugs and as a meme aimed at reducing harm among psychedelic users. Referring to non-pharmacological factors that shape drug experiences, the concept of set and setting was popularized in the West during the mid-20th century. However, little theoretical development has occurred...
We are in the midst of a psychedelic research renaissance. With research examining the efficacy of psychedelics as a treatment for a range of mental health indications still in its early stages, there is an increasing body of research to show that careful use of psychedelics can yield a variety of benefits in “healthy normals” and so lead to “the betterment of well people.” Psychedelics have...
Background and aims Given the enormous global burden of depressive illness, there is an urgent need to develop novel and more effective treatments for major depressive disorder (MDD). Recent findings have suggested that psychedelic drugs may have a role in the treatment of depressive symptoms, and a number of groups are in the process of developing protocols to study this question...
Background and aims Ayahuasca is a psychedelic decoction prepared from two (or more) plants containing monoamine oxidase inhibitors, N , N -dimethyltryptamine, and other chemicals. Ayahuasca has apparently been used for centuries in the Amazon basin of South America, and in recent years has increasingly been used internationally in diverse contexts. This study aims to elucidate differences...
This commentary considers efforts to turn psychedelics into medications that can be administered through healthcare systems as examples of “medicalization.” I draw on ethnographic research both inside and outside of university-based clinical trials from 2014 to date, together with analogous examples from psychiatry and drug research and development. Rather than taking a normative stance on...
Recent research suggests that psychedelic drugs can be powerful agents of change when utilized in conjunction with psychotherapy. Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy has been studied as a means of helping people overcome posttraumatic stress disorder, believed to work by reducing fear of traumatic memories and increasing feelings of trust and compassion toward others,...
The road to the current psychedelic renaissance in research on ±3,4-methylenedioxymethamphetamine (MDMA) – the active ingredient of the drug Ecstasy – for addressing treatment-resistant post-traumatic stress disorder has been fraught with political and academic bias, as well as cultural stigma among underserved populations, all of which serve as barriers to minority inclusion and participation....
In recent years, the study of psychedelic science has resurfaced as scientists and therapists are again exploring its potential to treat an array of psychiatric conditions, such as depression, post-traumatic stress disorder, and addiction. The scientific progress and clinical promise of this movement owes much of its success to the history of indigenous healing practices; yet the work of...
Introduction Once thought a rarely used drug, LSD use is steadily increasing among US adults. A greater understanding of social factors and psychological determinants leading to lifetime LSD use can assist health educators and professionals in treating this growing problem. This study analyzed psychosocial factors related to LSD use among a national sample of adults. Methods A secondary data...
This introduction to the special issue reviews research that supports the hypothesis that psychedelics, particularly psilocybin, were central features in the development of religion. The greater response of the human serotonergic system to psychedelics than is the case for chimpanzees’ serotonergic receptors indicates that these substances were environmental factors that affected hominin...
In this article, the origins of the cult of the ritual drink known as soma/haoma are explored. Various shortcomings of the main botanical candidates that have so far been proposed for this so-called “nectar of immortality” are assessed. Attention is brought to a variety of plants identified as soma/haoma in ancient Asian literature. Some of these plants are included in complex formulas and are...
In light of new historical evidence regarding ethnomycologist R. Gordon Wasson’s correspondence with art historian Erwin Panofsky, this article provides an in-depth analysis of the presence of entheogenic mushroom images in Christian art within the context of the controversy between Wasson and philologist John Marco Allegro over the identification of a Garden of Eden fresco in the 12th century...
Historical documents relating to early Mormonism suggest that Joseph Smith (1805–1844) employed entheogen-infused sacraments to fulfill his promise that every Mormon convert would experience visions of God and spiritual ecstasies. Early Mormon scriptures and Smith’s teachings contain descriptions consistent with using entheogenic material. Compiled descriptions of Joseph Smith’s earliest...
A commonly misunderstood area of Western psychedelic history involves psychoactive ointments that have become part of popular lore during the early modern and Renaissance eras. These substances amorphously considered as “flying ointments” have various histories. This paper addresses four separate histories regarding these beliefs: (a) one conveyed in the writings of anthropologist Michael...
The essay proposes that entheogenic mushrooms and shamanic experiences are encoded in the Khajuraho Temples of India. Erotic sculptures of Khajuraho have statues with limbs depicted in strange positions, separated from the body or with orientations that are anatomically impossible. These represent dismemberment experiences typical of shamanic and mystical initiation, a phenomenon with...
Not much is known from an ethnohistorical perspective about the use of psychoactive substances in southern Central America; it is mainly through the archeological record that their presence in the past has been inferred. This article reviews evidence for the use of mind-altering plants and mushrooms in the societies that inhabited the current Costa Rican territory during pre-Columbian times,...
Aims This heuristic study reports observations on the phenomenology of ayahuasca experiences of nine foreign tourist participants of an ayahuasca retreat in Peru. Methods Narrative interviews, reflecting individual experiences after ayahuasca “night ceremony,” have been analyzed by qualitative content analysis using a data-driven strategy in order to extract themes and categories inherent in...
Modern sophisticated archeometric instruments are increasingly capable of detecting the presence of psychoactive plant sources in archeological contexts, testifying the antiquity of humanity’s search for altered states of consciousness. The purpose of this article is to provide a general picture of these findings, covering the main psychoactive plant sources of the world, and identifying the...
This article collects evidence from psychopharmacology, scripture, and archeology to explore several preparations for consumption described in the Old Testament: Manna, Showbread, the Holy Ointment, and the Tabernacle Incense. The Ointment and the Incense are herbal preparations used by the priestly caste to facilitate a direct experience of the Israelite God. A wide variety of psychoactive...
Background and aims The psychoactive capacity of the alkaloid N,N-dimethyltryptamine (DMT) has been known for decades, and its presence in beverages used in religious contexts around the world – such as ayahuasca – has attracted growing attention from the scientific community due to its possible anxiolytic and antidepressant effects. Mimosa hostilis, popularly known as jurema preta in Brazil,...
In a letter to Humphrey Osmond in 1953, Aldous Huxley speculated about a “new system” of education in which psychedelics may play a part “by making it possible for young people to ‘taste and see’ what they have learned about at second hand, or directly but at a lower level of intensity, in the writings of the religious, or the works of poets, painters and musicians.” In 1968, the author...
Psychedelics have been investigated for their therapeutic applications in end-of-life care as early as 1960. Recently, there have been four main groups conducting clinical trials for either lysergic acid diethylamide or psilocybin for the treatment of anxiety and depression in patients with terminal illnesses. The recent trials have higher methodological quality and demonstrate the profound...