Eduardo José Crevelin - The Consciousness Library

Effects of ayahuasca on the endocannabinoid system of healthy volunteers and in volunteers with social anxiety disorder: Results from two pilot, proof‐of‐concept, randomized, placebo‐controlled trials

Human Psychopharmacology Clinical and Experimental February 2, 2022 Rafael G. Dos Santos, Juliana Mendes Rocha, Giordano Novak Rossi et al. 20 citations

Abstract Objective To assess endocannabinoid (anandamide, AEA; 2‐arachidonoylglycerol, 2‐AG) plasma levels in healthy volunteers and in volunteers with social anxiety disorder (SAD) after a single oral dose of ayahuasca or placebo. Methods Post hoc analysis of endocannabinoid plasma levels (baseline, 90 and 240 min after drug intake) from two parallel‐group, randomized, placebo‐controlled...

DOI: 10.1002/hup.2834 Ayahuasca Anxiety Placebo Endocannabinoid system +4

Effects of Ayahuasca on Personality: Results of Two Randomized, Placebo-Controlled Trials in Healthy Volunteers

Frontiers in Psychiatry August 6, 2021 Juliana Mendes Rocha, Giordano Novak Rossi, Flávia de Lima Osório et al. 37 citations

Rationale: Previous studies with the serotonergic hallucinogens LSD and psilocybin showed that these drugs induced changes in personality traits, such as increases in Openness. However, results are inconsistent, and the effects of ayahuasca on personality were never investigated in a controlled trial. Objectives: To assess the effects of ayahuasca on personality in two randomized,...

DOI: 10.3389/fpsyt.2021.688439 Ayahuasca Psilocybin Placebo Hallucinogen +4

Internet method for the extraction of N,N-dimethyltryptamine from Mimosa hostilis roots: Does it really extract dimethyltryptamine?

Journal of Psychedelic Studies March 1, 2019 Giordano Novak Rossi, Eduardo José Crevelin, Gabriela de Oliveira Silveira et al. 10 citations

Background and aims The psychoactive capacity of the alkaloid N,N-dimethyltryptamine (DMT) has been known for decades, and its presence in beverages used in religious contexts around the world – such as ayahuasca – has attracted growing attention from the scientific community due to its possible anxiolytic and antidepressant effects. Mimosa hostilis, popularly known as jurema preta in Brazil,...

DOI: 10.1556/2054.2019.009 Full text Dichloromethane Chloroform Ethyl acetate Extraction chemistry +7

Interactive Effects of Ayahuasca and Cannabidiol in Social Cognition in Healthy Volunteers: A Pilot, Proof-of-Concept, Feasibility, Randomized-Controlled Trial.

Journal of Clinical Psychopharmacology Giordano Novak Rossi, Juliana Mendes Rocha, Flávia L. Osório et al. 12 citations

Serotonergic hallucinogens and cannabinoids may alter the recognition of emotions in facial expressions (REFE). Cannabidiol (CBD) attenuates the psychoactive effects of the cannabinoid-1 agonist tetrahydrocannabinol. Ayahuasca is a dimethyltryptamine-containing hallucinogenic decoction. It is unknown if CBD may moderate and attenuate the effects of ayahuasca on REFE. Seventeen healthy...

DOI: 10.1097/jcp.0000000000001691 Full text Psychedelics Plant medicine Clinical research Mental health

Papers

Effects of ayahuasca on the endocannabinoid system of healthy volunteers and in volunteers with social anxiety disorder: Results from two pilot, proof‐of‐concept, randomized, placebo‐controlled trials

Effects of Ayahuasca on Personality: Results of Two Randomized, Placebo-Controlled Trials in Healthy Volunteers

Internet method for the extraction of N,N-dimethyltryptamine from Mimosa hostilis roots: Does it really extract dimethyltryptamine?

Interactive Effects of Ayahuasca and Cannabidiol in Social Cognition in Healthy Volunteers: A Pilot, Proof-of-Concept, Feasibility, Randomized-Controlled Trial.