A light-induced cyclization via a radical spin-center shift process that results in the direct functionalization of the indole ring at the C4-position is developed into a practical method for the synthesis of medicinally active, ring-constrained tryptamine analogs. Amino acids were coupled to tryptamine and irradiated with UV light to produce a library of lactams bridging the C3- and...
Recent research has relied on the use of fine-tuning techniques to incorporate philosophical knowledge into Large Language Models (LLMs). The present paper outlines an alternative approach to the development of such systems—one that is rooted in a technique known as Retrieval-Augmented Generation (RAG). In contrast to fine-tuning, RAG does not seek to adjust the internal parameters (or internal...
The emerging neurocomputational vision of humans as embodied, ecologically embedded, social agents—who shape and are shaped by their environment—offers a golden opportunity to revisit and revise ideas about the physical and information-theoretic underpinnings of life, mind, and consciousness itself. In particular, the active inference framework (AIF) makes it possible to bridge connections from...