Journal of the American Chemical Society
December 16, 2025
J.O.S. Beckett, Ryan Buzdygon, Steven Nguyen et al.
1 citation
A light-induced cyclization via a radical spin-center shift process that results in the direct functionalization of the indole ring at the C4-position is developed into a practical method for the synthesis of medicinally active, ring-constrained tryptamine analogs. Amino acids were coupled to tryptamine and irradiated with UV light to produce a library of lactams bridging the C3- and...
Synthese
June 1, 2025
Paul R. Smart, Robert W. Clowes, A. Clark
Recent research has relied on the use of fine-tuning techniques to incorporate philosophical knowledge into Large Language Models (LLMs). The present paper outlines an alternative approach to the development of such systems—one that is rooted in a technique known as Retrieval-Augmented Generation (RAG). In contrast to fine-tuning, RAG does not seek to adjust the internal parameters (or internal...
Frontiers in Robotics and AI
March 8, 2018
A. Linson, A. Clark, S. Ramamoorthy et al.
94 citations
The emerging neurocomputational vision of humans as embodied, ecologically embedded, social agents—who shape and are shaped by their environment—offers a golden opportunity to revisit and revise ideas about the physical and information-theoretic underpinnings of life, mind, and consciousness itself. In particular, the active inference framework (AIF) makes it possible to bridge connections from...
International Conference on Entity-Relationship Approach
2003
A. Clark
In the movie, Memento, the hero, Leonard, suffers from a form of anterograde amnesia that results in an inability to lay down new memories. Nonetheless, he sets out on a quest to find his wife’s killer, aided by the use of notes, annotated polaroids, and (for the most important pieces of information obtained) body tattoos. Using these resources he attempts to build up a stock of new beliefs and...