Journal of the American Chemical Society
December 16, 2025
J.O.S. Beckett, Ryan Buzdygon, Steven Nguyen et al.
1 citation
A light-induced cyclization via a radical spin-center shift process that results in the direct functionalization of the indole ring at the C4-position is developed into a practical method for the synthesis of medicinally active, ring-constrained tryptamine analogs. Amino acids were coupled to tryptamine and irradiated with UV light to produce a library of lactams bridging the C3- and...
Journal of Psychoactive Drugs
March 15, 2025
Trey Brasher, David Rosen, Marcello Spinella
1 citation
Recent clinical trials on classic psychedelics for depression and anxiety have raised questions about their potential to treat other psychiatric conditions. Evidence from pre-clinical and clinical research suggests psychedelics may help with substance use disorders, with ongoing registered trials. Behavioral addictions, sharing features with substance addictions, may also respond to psychedelic...
Frontiers in Psychiatry
September 19, 2023
Hillary Jackson, Sara So, Abigail Yaffe et al.
87 citations
Introduction The classic psychedelic psilocybin, found in some mushroom species, has received renewed interest in clinical research, showing potential mental health benefits in preliminary trials. Naturalistic use of psilocybin outside of research settings has increased in recent years, though data on the public health impact of such use remain limited. Methods This prospective, longitudinal...
International Journal of Wellbeing
February 28, 2023
Trey Brasher, David Rosen, Marcello Spinella
9 citations
Classical psychedelics appear efficacious in improving psychological well-being in randomized clinical trials, but their effects in the population at large are relatively unknown. In the present paper, which includes three studies conducted by online survey with a collective 3,157 participants, classical psychedelic users showed greater psychological strengths and well-being, and lower levels...