Transforming Amino Acids into Serotonin 5-HT 2A Receptor Ligands Using Photochemistry
Journal of the American Chemical Society December 16, 2025 J.O.S. Beckett, Ryan Buzdygon, Steven Nguyen et al. 1 citation
A light-induced cyclization via a radical spin-center shift process that results in the direct functionalization of the indole ring at the C4-position is developed into a practical method for the synthesis of medicinally active, ring-constrained tryptamine analogs. Amino acids were coupled to tryptamine and irradiated with UV light to produce a library of lactams bridging the C3- and...