Neuropsychopharmacology
December 2013
Shigeyuki Yamamoto, Hiroyuki Ohba, Shingo Nishiyama et al.
Subanesthetic doses of ketamine, an N-methyl-D-aspartic acid (NMDA) antagonist, have a rapid antidepressant effect which lasts for up to 2 weeks. However, the neurobiological mechanism regarding this effect remains unclear. In the present study, the effects of subanesthetic doses of ketamine on serotonergic systems in conscious monkey brain were investigated. Five young monkeys underwent four...
Schizophrenia Bulletin
September 1, 2012
Edward F. Domino, Elliot D. Luby
The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology...
Anesthesiology
August 6, 2010
Edward F. Domino, David S. Warner
517 citations
Pharmacologic actions of CI-581, a chemical derivative of phencyclidine, were determined in 20 volunteers from a prison population. The results indicate that this drug is an effective analgesic and anesthetic agent in doses of 1.0 to 2.0 mg per kilogram. With intravenous administration the onset of action is within 1 min and the effects last for about 5 to 10 min, depending on dosage level and...
Animal Models in Human Psychobiology
1976
Edward F. Domino
3 citations
To say the least, the literature on indole hallucinogens and schizophrenia is confusing. This is because investigators who have access to schizophrenic patients do not have sophisticated gas chromatographic and mass spectrographic facilities, and those chemically sophisticated researchers who have such analytic facilities do not have access to a suitable patient research population. This...
Clinical Pharmacology & Therapeutics
May 1, 1965
Edward F. Domino, Peter Chodoff, Guenter Corssen
Pharmacologic actions of CI‐581, a chemical derivative of phencyclidine, were determined in 20 volunteers from a prison population. The results indicate that this drug is an effective analgesic and anesthetic agent in doses of 1.0 to 2.0 mg. per kilogram. With intravenous administration the onset of action is within 1 minute and the effects last for about 5 to 10 minutes, depending on dosage...