Phencyclidine/schizophrenia: one view toward the past, the other to the future.
Edward F. Domino, Elliot D. Luby
Schizophrenia Bulletin September 1, 2012 DOI: 10.1093/schbul/sbs011 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Historical analysis Peer reviewed |
|---|---|
| Key points | Argues that research on phencyclidine and its derivative ketamine has provided a foundation for understanding the neuropathology of schizophrenia. |
Abstract
The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.
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Cites 8
- Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans Archives of General Psychiatry March 1, 1994
- Recent advances in the phencyclidine model of schizophrenia American Journal of Psychiatry October 1, 1991
- Study of a New Schizophrenomimetic Drug—Sernyl Archives of Neurology And Psychiatry March 1, 1959
- Effects of LSD-25 on the EEG and Photic Evoked Responses Archives of General Psychiatry April 1, 1966
- Effects of ketamine in normal and schizophrenic volunteers. Neuropsychopharmacology October 1, 2001
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