Phencyclidine/schizophrenia: one view toward the past, the other to the future.
Edward F. Domino, Elliot D. Luby
Schizophrenia Bulletin September 1, 2012 DOI: 10.1093/schbul/sbs011 (opens in new tab) via PubMed
Summary
AI-generated from the abstractPhencyclidine, originally developed as a general anesthetic, has also been used as a chemical model of schizophrenia and as a drug of abuse. Research on phencyclidine and its chemical derivatives, such as ketamine, has laid a foundation for understanding the neuropathology of schizophrenia, though this understanding is still in its early stages.
Study at a glance
| Characteristics | Historical analysis Peer reviewed |
|---|---|
| Key finding | Argues that research on phencyclidine and its derivative ketamine has provided a foundation for understanding the neuropathology of schizophrenia. |
Abstract
The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.