Subanesthetic doses of ketamine transiently decrease serotonin transporter activity: a PET study in conscious monkeys.
Neuropsychopharmacology December 2013 Shigeyuki Yamamoto, Hiroyuki Ohba, Shingo Nishiyama et al.
Subanesthetic doses of ketamine, an N-methyl-D-aspartic acid (NMDA) antagonist, have a rapid antidepressant effect which lasts for up to 2 weeks. However, the neurobiological mechanism regarding this effect remains unclear. In the present study, the effects of subanesthetic doses of ketamine on serotonergic systems in conscious monkey brain were investigated. Five young monkeys underwent four...