Hiroyuki Ohba

2 papers in the library · 125 citations · publishing 2013-2016

Papers

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Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys

European Archives of Psychiatry and Clinical Neuroscience April 18, 2016 Kenji Hashimoto, Takeharu Kakiuchi, Hiroyuki Ohba et al. 125 citations

R-ketamine appears to be a potent, long-lasting and safer antidepressant, relative to esketamine (S-ketamine), since it might be free of psychotomimetic side effects. Using [11C]raclopride and positron emission tomography (PET), we investigated whether esketamine and R-ketamine can affect dopamine D2/3 receptor binding in the conscious monkey brain. A single infusion of esketamine (0.5 mg/kg),...

DOI: 10.1007/s00406-016-0692-7 Ketamine Psychotomimetic Raclopride Dopamine receptor d2 +5

Subanesthetic doses of ketamine transiently decrease serotonin transporter activity: a PET study in conscious monkeys.

Neuropsychopharmacology December 2013 Shigeyuki Yamamoto, Hiroyuki Ohba, Shingo Nishiyama et al.

Subanesthetic doses of ketamine, an N-methyl-D-aspartic acid (NMDA) antagonist, have a rapid antidepressant effect which lasts for up to 2 weeks. However, the neurobiological mechanism regarding this effect remains unclear. In the present study, the effects of subanesthetic doses of ketamine on serotonergic systems in conscious monkey brain were investigated. Five young monkeys underwent four...

DOI: 10.1038/npp.2013.176 Full text