Journal of molecular neuroscience : MN
July 12, 2025
Weihao Fan, Yi Ye, Hongkun Yang et al.
1 citation
Ketamine is a synthesized anesthetic drug that was used extensively as a surgical anesthetic in the 1960s. Currently, ketamine is being investigated extensively for its potential as a treatment for depression. However, the addictive nature of ketamine has become an issue that cannot be ignored at this stage. As of now, there is no clear understanding of the changes in striatal metabolites and...
Neuroimage
May 15, 2025
Aya Khalaf, Erick Lopez, Jian Li et al.
6 citations
Subcortical arousal systems are known to play a key role in controlling sustained changes in attention and conscious awareness. Recent studies indicate that these systems have a major influence on short-term dynamic modulation of visual attention, but their role across sensory modalities is not fully understood. In this study, we investigated shared subcortical arousal systems across sensory...
Science Translational Medicine
May 1, 2024
Brian L Edlow, Mark Olchanyi, Holly J Freeman et al.
39 citations
Consciousness is composed of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that underlie awareness in the human brain, but knowledge about the subcortical networks that sustain arousal in humans is incomplete. Here, we aimed to map the connectivity of a proposed subcortical arousal network that sustains wakefulness in the human...
bioRxiv Preprint Server
July 13, 2023
Brian L Edlow, Mark Olchanyi, Holly J Freeman et al.
preprint
Consciousness is comprised of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that modulate awareness in the human brain, but knowledge about the subcortical networks that sustain arousal is lacking. We integrated data from ex vivo diffusion MRI, immunohistochemistry, and in vivo 7 Tesla functional MRI to map the connectivity of a...
bioRxiv
July 14, 2021
Jian Li, W. Curley, B. Guérin et al.
preprint
The default mode network (DMN) mediates self-awareness and introspection, core components of human consciousness. Therapies to restore consciousness in patients with severe brain injuries have historically targeted subcortical sites in the brainstem, thalamus, hypothalamus, basal forebrain, and basal ganglia, with the goal of reactivating cortical DMN nodes. However, the subcortical...
Proceedings of the National Academy of Sciences of the United States of America
June 2, 2009
Yi-Yuan Tang, Yinghua Ma, Yaxin Fan et al.
Five days of integrative body-mind training (IBMT) improves attention and self-regulation in comparison with the same amount of relaxation training. This paper explores the underlying mechanisms of this finding. We measured the physiological and brain changes at rest before, during, and after 5 days of IBMT and relaxation training. During and after training, the IBMT group showed significantly...