Cortex; a journal devoted to the study of the nervous system and behavior
August 1, 2026
Matteo Fecchio, David R Schreier, Morgan K Cambareri et al.
Early detection of consciousness in critically ill patients with severe brain injuries can profoundly impact prognostication and clinical care decisions. Advanced multimodal protocols to detect signs of consciousness include standardized behavioral assessments, task-based functional magnetic resonance imaging (fMRI), and task-based electroencephalography (EEG). However, these approaches have...
Neurology
February 25, 2025
David Fischer, Brian L Edlow, Holly J Freeman et al.
9 citations
Determining the level of consciousness in patients with brain injury-and more fundamentally, establishing what they can experience-is ethically and clinically impactful. Patient behaviors may unreliably reflect their level of consciousness: a subset of unresponsive patients demonstrate covert consciousness by willfully modulating their brain activity to commands through fMRI or EEG. However,...
Science Translational Medicine
May 1, 2024
Brian L Edlow, Mark Olchanyi, Holly J Freeman et al.
39 citations
Consciousness is composed of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that underlie awareness in the human brain, but knowledge about the subcortical networks that sustain arousal in humans is incomplete. Here, we aimed to map the connectivity of a proposed subcortical arousal network that sustains wakefulness in the human...
bioRxiv Preprint Server
July 13, 2023
Brian L Edlow, Mark Olchanyi, Holly J Freeman et al.
preprint
Consciousness is comprised of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that modulate awareness in the human brain, but knowledge about the subcortical networks that sustain arousal is lacking. We integrated data from ex vivo diffusion MRI, immunohistochemistry, and in vivo 7 Tesla functional MRI to map the connectivity of a...