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Michele A. Colombo

2 papers in the library · 359 citations · publishing 2019-2025

Papers

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Thermodynamics of consciousness: A non-invasive perturbational framework

bioRxiv Preprint Server December 9, 2025 Tomas Berjaga-Buisan, Juan Manuel Monti, Martina Cortada et al. preprint

The quest for reliable and objective measures of consciousness is critical in basic and clinical neuroscience. Across species, the Perturbational Complexity Index (PCI) has emerged as a robust empirical marker by directly perturbing the brain, yet its underlying principles of physics are not fully understood. Here, we bridge this gap by introducing a non-invasive framework based on generative...

The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine

Neuroimage January 11, 2019 Michele A. Colombo, Martino Napolitani, Melanie Boly et al. 359 citations

Despite the absence of responsiveness during anesthesia, conscious experience may persist. However, reliable, easily acquirable and interpretable neurophysiological markers of the presence of consciousness in unresponsive states are still missing. A promising marker is based on the decay-rate of the power spectral density (PSD) of the resting EEG. We acquired resting electroencephalogram (EEG)...