Psychotherapy and Psychosomatics
June 12, 2026
Thorsten Barnhofer, Maria Niemi, Johannes Michalak et al.
1 citation
INTRODUCTION: Around a third of patients with major depressive disorder experience persistent symptoms despite usual treatments. Identifying scalable, psychological treatment options is critical to reduce the burden associated with difficult-to-treat depression (DTD). We examined the efficacy of mindfulness-based cognitive therapy (MBCT) compared with treatment as usual (TAU) and other active...
The European Journal of Psychiatry
March 7, 2026
Rocío Gómez-juanes, Guillermo Mompaler Lázaro, Adoración Castro et al.
1 citation
Intranasal esketamine represents a novel therapeutic option for Treatment-Resistant Depression (TRD). However, its medium-to-long-term risk-benefit profile in real-world clinical practice remains controversial. Limited data is available regarding its effectiveness, particularly in patients who have not responded to electroconvulsive therapy (ECT), which is the focus of this study. We conducted...
BMJ Open
December 8, 2025
Thorsten Barnhofer, Maria Niemi, Johannes Michalak et al.
Introduction: About 30% of depressed patients suffer from a protracted course in which the disorder continues to cause significant burden despite treatment efforts. While originally developed for relapse prevention, mindfulness-based cognitive therapy (MBCT) has increasingly been investigated in depressed patients with such 'difficult-to-treat' courses. This is a protocol for an individual...
medRxiv
June 9, 2025
Thorsten Barnhofer, Maria Niemi, Johannes Michalak et al.
preprint
ABSTRACT: Introduction: About 30% of depressed patients suffer from a protracted course in which the disorder continues to cause significant burden despite treatment efforts. While originally developed for relapse prevention, Mindfulness-Based Cognitive Therapy (MBCT) has increasingly been investigated in depressed patients with such ‘difficult-to-treat’ courses. This is a protocol for an...
Frontiers in Psychology
2023
Mauro Garcia-Toro, Alejandra Aguilar-Latorre, Aurora Garcia et al.
The COVID-19 pandemic and consequent physical distancing has made it difficult to provide care for those with Treatment-Resistant Depression (TRD). As a secondary analysis of a clinical trial, the aim of this study was to explore potential mechanisms through which three online-delivered approaches, added to treatment as usual, improve depressive symptoms in TRD patients. The three approaches...
Psychosocial Intervention
November 1, 2019
Noemí Sansó, Laura Galiana, B. González et al.
espanolEl objetivo de este trabajo fue evaluar la eficacia diferencial de dos intervenciones para mejorar la calidad de vida de profesionales de atencion primaria de Mallorca: un programa de reduccion del estres basado en mindfulness (MBSRt) y un entrenamiento en cultivo de la compasion (CCT). Participaron 50 profesionales, el 81% de los cuales eran mujeres. Se evaluo mindfulness, empatia,...
Frontiers in Psychology
March 8, 2019
F. Parmentier, Mauro Garcia-Toro, Javier García-campayo et al.
The present study examined the effects of mindfulness on depression and anxiety, both direct and indirect through the mediation of four mechanisms of emotional regulation: worry, rumination, reappraisal and suppression. Path analysis was applied to data collected from an international and non-clinical sample of 1151 adults, including both meditators and non-meditators, who completed an online...
BMC Complementary and Alternative Medicine
February 23, 2017
Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero et al.
Only a small number of articles have investigated the relationship between mindfulness-based interventions (MBIs) and biomarkers. The aim of this systematic review was to study the effect of MBIs on specific biomarkers (cytokines, neuropeptides and C-reactive protein (CRP)) in both healthy subjects and cancer patients. A search was conducted using PubMed, EMBASE, PsycINFO and the Cochrane...