Ketamine and its structural analog, 2-Fluorodeschloroketamine, both potent stimulants, can induce euphoria but also cause neurotoxicity, cognitive decline, and neurodevelopmental deficits in the fetus. However, the molecular mechanisms responsible for these neurodevelopmental abnormalities are not yet fully elucidated, particularly concerning effects that are specific to certain cell types....
To evaluate the association of a short-term mindfulness-based stress reduction program combined with auricular acupressure with preoperative sleep fragmentation, anxiety, pain, and physiological stress responses in patients with spinal metastases using a retrospective quasi-experimental before-and-after design. This retrospective quasi-experimental before-and-after cohort study included...
BACKGROUND Obesity, characterized by excessive adiposity, is associated with brain structural abnormalities. Nevertheless, the relationships between altered structural node of default mode network (DMN), body mass index (BMI), general cognitive ability remained unclear in young adults. METHODS In this study, we divided a large sample of young adults into three BMI-based groups. We then...
An increasing number of studies have used positron emission tomography (PET) to investigate molecular neurobiological differences in individuals who use cannabis. This study aimed to systematically review PET imaging research in individuals who use cannabis or have cannabis use disorder (CUD). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria, a...
ABSTRACT Ketamine, an N‐methyl‐d‐aspartic acid receptor (NMDAR) antagonist, elicits rapid‐acting and sustained antidepressant effects in treatment‐resistant depressed patients. Accumulating evidence suggests that gut microbiota via the gut‐brain axis play a role in the pathogenesis of depression, thereby contributing to the antidepressant actions of certain compounds. Here we investigated the...