F1000Research
June 25, 2026
Tomoyuki Nagayama, Kazuo Koyama, Tsuyoshi Takada
Background Although drives cannot be demonstrated to be quantum phenomena, the formulation proceeds by defining drives in terms of their neural correlates and by hypothesizing that the indeterminacy associated with consciousness arises from the indeterminacy of drives. We also explore interventions using either–or questions designed to foster emotional awareness related to changes in drive....
F1000Research
June 25, 2026
Kyoko Kusano, Hayato Saigo, Naotsugu Tsuchiya
Abstract* Characterizing qualitative aspects of subjective experiences, qualia, remains a challenging open problem. The recent Qualia structure paradigm proposes capturing qualia through massive relations with other qualia. A concrete method for this involves measuring pairwise similarities. This approach has been successfully applied to reveal similarities and differences in qualia structures...
F1000Research
January 10, 2025
Brandon M. Brooks, Francisco J. Cordero, Stephen L. Alchermes et al.
3 citations
Social pain is emotional distress caused by harm or threat to social connections that results in social exclusion, rejection, or loss. Social Pain is also a potentiator of physical pain. Supportive social relationships are widely recognized for their impact on maintaining health and well-being. The Passion of Jesus Christ serves as a quintessential example of social pain (i.e., desertion,...
F1000Research
September 5, 2024
Nigel A Shaw
Near-death experience (NDE) is a transcendent mental event of uncertain etiology that arises on the cusp of biological death. Since the discovery of NDE in the mid-1970s, multiple neuroscientific theories have been developed in an attempt to account for it in strictly materialistic or reductionistic terms. Therefore, in this conception, NDE is at most an extraordinary hallucination without any...
F1000Research
2024
Nigel A Shaw
2 citations
Near-death experience (NDE) is a transcendent mental event of uncertain etiology that arises on the cusp of biological death. Since the discovery of NDE in the mid-1970s, multiple neuroscientific theories have been developed in an attempt to account for it in strictly materialistic or reductionistic terms. Therefore, in this conception, NDE is at most an extraordinary hallucination without any...
F1000Research
November 25, 2022
T. Honda
Background: Mindfulness meditation for chronic pain is popular globally, but evidence of its efficacy is limited. Moreover, there are no established methods on the objective evaluation of the effectiveness of interventions for chronic pain. In this study, a chronic low back pain patient was treated with traditional Japanese Buddhism meditation-integrated cognitive behavioral therapy and the...
F1000Research
September 7, 2022
Andrew B. Newberg, Nancy Wintering, Chloe Hriso et al.
1 citation
Background: The relationship between sexuality, or the libido, and spirituality or religion has long been debated in psychiatry. Recent studies have explored the neurophysiology of both sexual experiences and spiritual practices such as meditation or prayer. In the present study, we report changes in cerebral glucose metabolism in a unique meditation practice augmented by clitoral stimulation...
F1000Research
September 23, 2021
Kevin Mckernan, Liam T. Kane, Yvonne Helbert et al.
10 citations
The Psilocybe genus is well known for the synthesis of valuable psychoactive compounds such as Psilocybin, Psilocin, Baeocystin and Aeruginascin. The ubiquity of Psilocybin synthesis in Psilocybe has been attributed to a horizontal gene transfer mechanism of a ~20Kb gene cassette. A recently published highly contiguous reference genome derived from long read single molecule sequencing has...
F1000Research
July 22, 2021
Vivian Siegel, Benjamin Emmert-Aronson
5 citations
Background: Practitioners in a variety of spiritual/religious traditions have described “mystical experiences”, defined by a common set of qualities. The “Mystical Experience Questionnaire” (MEQ30) provides a validated and quantitative measure of mystical experience, and has been used successfully to demonstrate that the hallucinogenic substance psilocybin triggers a mystical-type experience....
F1000Research
June 25, 2021
Helané Wahbeh, Nina Fry, Paolo Speirn et al.
2 citations
The term "noetic" comes from the Greek word noēsis/noētikos that means inner wisdom, direct knowing, intuition, or implicit understanding. Strong cultural taboos exist about sharing these experiences. Thus, many may not feel comfortable transparently discussing or researching these topics, despite growing evidence that these experiences may be real. The study's objective was to qualitatively...
F1000Research
June 15, 2021
Kevin Mckernan, Liam T. Kane, Seth Crawford et al.
10 citations
We describe the use of high-fidelity single molecule sequencing to assemble the genome of the psychoactive Psilocybe cubensis mushroom. The genome is 46.6Mb, 46% GC, and in 32 contigs with an N50 of 3.3Mb. The BUSCO completeness scores are 97.6% with 1.2% duplicates. The Psilocybin synthesis cluster exists in a single 3.2Mb contig. The dataset is available from NCBI BioProject with accessions...
F1000Research
April 9, 2021
Kevin Mckernan, Liam T. Kane, Seth Crawford et al.
3 citations
We describe the use of high-fidelity single molecule sequencing to assemble the genome of the psychoactive Psilocybe cubensis mushroom. The genome is 46.6Mb, 46% GC, and in 32 contigs with an N50 of 3.3Mb. The BUSCO completeness scores are 97.6% with 1.2% duplicates. The Psilocybin synthesis cluster exists in a single 3.2Mb contig. The dataset is available from NCBI BioProject with accessions...
F1000Research
March 15, 2021
Prinya Musikaphongsakul, Kimheang Ya, Pakpoom Subsoontorn et al.
6 citations
Background: Psilocybin (PB) is a psychoactive compound commonly found in magic mushroom (Psilocybe cubensis). PB is quickly converted by the body to psilocin (PI), which has a psychedelic effect through the activation of the 5-HT2A receptor in the brain. The objective of this study is to develop a physiologically based pharmacokinetic (PBPK) model of PB and PI in rats and humans for predicting...
F1000Research
May 14, 2020
Helané Wahbeh, Garret Yount, Cassandra Vieten et al.
13 citations
Background: Belief in the paranormal is widespread worldwide. Recent surveys suggest that subjective experiences of the paranormal are common. A concise instrument that adequately evaluates beliefs as distinct from experiences does not currently exist. To address this gap, we created the Noetic Experiences and Beliefs Scale (NEBS) which evaluates belief and experience as separate constructs....
F1000Research
2019
Helané Wahbeh, Cedric Cannard, Jennifer Okonsky et al.
21 citations
Background: Numerous world cultures believe channeling provides genuine information, and channeling rituals in various forms are regularly conducted in both religious and non-religious contexts. Little is known about the physiological correlates of the subjective experience of channeling. Methods: We conducted a prospective within-subject design study with 13 healthy adult trance channels....
F1000Research
May 24, 2018
Ronald S. Duman
203 citations
Therapeutic medications for the treatment of depression have serious limitations, particularly delayed onset and low rates of efficacy. However, the discovery that a single subanesthetic dose of ketamine, a glutamate NMDA receptor channel blocker, can produce a rapid (within hours) antidepressant response that is sustained (about 1 week), even in patients considered treatment-resistant, has...
F1000Research
2017
Patrizio Tressoldi, Enrico Facco, Daniela Lucangeli
In this essay, we will support the claim that at the current level of scientific advancement a) some first-person accounts cannot be reduced to their third-person neural and psychophysiological correlates and b) that these first-person accounts are the only information to reckon when it is necessary to analyse qualia contents. Consequently, for many phenomena, first-person accounts are the only...
F1000Research
January 29, 2016
Daryl Bem, Patrizio Tressoldi, Thomas Rabeyron et al.
78 citations
In 2011, one of the authors (DJB) published a report of nine experiments in the Journal of Personality and Social Psychology purporting to demonstrate that an individual's cognitive and affective responses can be influenced by randomly selected stimulus events that do not occur until after his or her responses have already been made and recorded, a generalized variant of the phenomenon...
F1000Research
March 28, 2013
Teri Suzanne Krebs, Pål-ørjan Johansen
125 citations
We estimated lifetime prevalence of psychedelic use (lysergic acid diethylamide (LSD), psilocybin (magic mushrooms), mescaline, and peyote) by age category using data from a 2010 US population survey of 57,873 individuals aged 12 years and older. There were approximately 32 million lifetime psychedelic users in the US in 2010; including 17% of people aged 21 to 64 years (22% of males and 12% of...