Background Hybrid learning requires students to sustain attention, regulate emotions, and use technology purposefully across physical and virtual spaces. Digital mindfulness has mainly been studied as a means of reducing psychological distress; its role as a pedagogical strategy for engagement has not been systematically synthesised. We aimed to identify the forms of digital mindfulness...
Abstract* Characterizing qualitative aspects of subjective experiences, qualia, remains a challenging open problem. The recent Qualia structure paradigm proposes capturing qualia through massive relations with other qualia. A concrete method for this involves measuring pairwise similarities. This approach has been successfully applied to reveal similarities and differences in qualia structures...
Background Although drives cannot be demonstrated to be quantum phenomena, the formulation proceeds by defining drives in terms of their neural correlates and by hypothesizing that the indeterminacy associated with consciousness arises from the indeterminacy of drives. We also explore interventions using either–or questions designed to foster emotional awareness related to changes in drive....
F1000ResearchJanuary 10, 2025Brandon M. Brooks, Francisco J. Cordero, Stephen L. Alchermes et al.3 citations
Social pain is emotional distress caused by harm or threat to social connections that results in social exclusion, rejection, or loss. Social Pain is also a potentiator of physical pain. Supportive social relationships are widely recognized for their impact on maintaining health and well-being. The Passion of Jesus Christ serves as a quintessential example of social pain (i.e., desertion,...
Background The use of mindfulness in the treatment of anxiety and depression is becoming more and more widespread, but there are few reports that it has fundamentally changed patients’ sense of life. Case Presentation This report showed 9 year’s progress of treatment for Social Anxiety Disorder and Persistent Depressive Disorder in a 41-year-old female patient experiencing a long-term painful...
Near-death experience (NDE) is a transcendent mental event of uncertain etiology that arises on the cusp of biological death. Since the discovery of NDE in the mid-1970s, multiple neuroscientific theories have been developed in an attempt to account for it in strictly materialistic or reductionistic terms. Therefore, in this conception, NDE is at most an extraordinary hallucination without any...
F1000ResearchJune 12, 2024Chaitali S. Vikhe, Swapnil U. Ramteke
Background The Patellofemoral Pain Syndrome (PFPS) poses a significant challenge in sports medicine due to its multifactorial etiology involving both physiological and psychological factors. Though widely used, conventional physiotherapy approaches often yield limited efficacy and high recurrence rates. Mindfulness-based interventions have emerged as promising adjuncts in managing various...
Near-death experience (NDE) is a transcendent mental event of uncertain etiology that arises on the cusp of biological death. Since the discovery of NDE in the mid-1970s, multiple neuroscientific theories have been developed in an attempt to account for it in strictly materialistic or reductionistic terms. Therefore, in this conception, NDE is at most an extraordinary hallucination without any...
F1000ResearchSeptember 28, 2023Yehudit Shabat, Yaron Ilan
Background: No evidence of the possibility to alter a constituent of the immune system without directly affecting one of its associated components has been shown yet. Methods: A schematic model was developed in which two triggers, fasting and splenectomy, were studied for their ability to affect the expression of cell membrane epitopes and the cytokine secretion of out-of-body autogeneic and...
F1000ResearchJuly 4, 2023David Duarte, Cabral Lima, Priscila M. V. Lima et al.2 citations
Background: Brain-Computer Interface (BCI) systems allow the use of electroencephalographic activities to control devices. As such, it can be an important tool for disabled people since using a BCI does not involves any muscular stimulation. Despite its great potential as an assistive technology, BCI systems are yet scarcely available outside scientific contexts. The main reason is that BCI is...
Awe, a complex emotion, arises in response to perceptually and conceptually vast stimuli that transcend one's current frames of reference, which is associated with subjective psychological phenomena, such as a sense of self and consciousness. This study aimed to develop a Japanese version of the Awe Experience Scale (AWE-S), a widely used questionnaire that robustly measured the state of awe,...
Background: Mindfulness meditation for chronic pain is popular globally, but evidence of its efficacy is limited. Moreover, there are no established methods on the objective evaluation of the effectiveness of interventions for chronic pain. In this study, a chronic low back pain patient was treated with traditional Japanese Buddhism meditation-integrated cognitive behavioral therapy and the...
Background: Immediately after graduation from university, college students need to make significant decisions about starting their careers or pursuing higher studies. They are also pressured to meet the expectations and demands of self, others, and the environment. Owing to the impact of the COVID-19 pandemic, the aforementioned challenging decisions may become hazardous stressors for college...
Background: The relationship between sexuality, or the libido, and spirituality or religion has long been debated in psychiatry. Recent studies have explored the neurophysiology of both sexual experiences and spiritual practices such as meditation or prayer. In the present study, we report changes in cerebral glucose metabolism in a unique meditation practice augmented by clitoral stimulation...
F1000ResearchMarch 2, 2022Vivian Siegel, Caryn Roth, Elisabeth Bolaza et al.
Background: Orgasmic Meditation (OM) is a structured, partnered meditative practice in which one person, who can be any gender, strokes the clitoris of their partner for 15 minutes. As such, it resembles a sexual activity. OM is taught as a practice that is distinct from sex, and we wondered whether people who engage in OM actually maintain that distinction themselves. Methods: We conducted an...
Background: A majority of previous studies appear to support a view that human observers can only perceive coarse information from a natural scene image when it is presented rapidly (<100ms, masked). In these studies, participants were often forced to choose an answer from options that experimenters preselected. These options can underestimate what participants experience and can report on it....
The Psilocybe genus is well known for the synthesis of valuable psychoactive compounds such as Psilocybin, Psilocin, Baeocystin and Aeruginascin. The ubiquity of Psilocybin synthesis in Psilocybe has been attributed to a horizontal gene transfer mechanism of a ~20Kb gene cassette. A recently published highly contiguous reference genome derived from long read single molecule sequencing has...
F1000ResearchJuly 22, 2021Vivian Siegel, Benjamin Emmert-Aronson5 citations
Background: Practitioners in a variety of spiritual/religious traditions have described “mystical experiences”, defined by a common set of qualities. The “Mystical Experience Questionnaire” (MEQ30) provides a validated and quantitative measure of mystical experience, and has been used successfully to demonstrate that the hallucinogenic substance psilocybin triggers a mystical-type experience....
The term "noetic" comes from the Greek word noēsis/noētikos that means inner wisdom, direct knowing, intuition, or implicit understanding. Strong cultural taboos exist about sharing these experiences. Thus, many may not feel comfortable transparently discussing or researching these topics, despite growing evidence that these experiences may be real. The study's objective was to qualitatively...
We describe the use of high-fidelity single molecule sequencing to assemble the genome of the psychoactive Psilocybe cubensis mushroom. The genome is 46.6Mb, 46% GC, and in 32 contigs with an N50 of 3.3Mb. The BUSCO completeness scores are 97.6% with 1.2% duplicates. The Psilocybin synthesis cluster exists in a single 3.2Mb contig. The dataset is available from NCBI BioProject with accessions...
We describe the use of high-fidelity single molecule sequencing to assemble the genome of the psychoactive Psilocybe cubensis mushroom. The genome is 46.6Mb, 46% GC, and in 32 contigs with an N50 of 3.3Mb. The BUSCO completeness scores are 97.6% with 1.2% duplicates. The Psilocybin synthesis cluster exists in a single 3.2Mb contig. The dataset is available from NCBI BioProject with accessions...
F1000ResearchMarch 15, 2021Prinya Musikaphongsakul, Kimheang Ya, Pakpoom Subsoontorn et al.6 citations
Background: Psilocybin (PB) is a psychoactive compound commonly found in magic mushroom (Psilocybe cubensis). PB is quickly converted by the body to psilocin (PI), which has a psychedelic effect through the activation of the 5-HT2A receptor in the brain. The objective of this study is to develop a physiologically based pharmacokinetic (PBPK) model of PB and PI in rats and humans for predicting...
Background: Psi research is a controversial area of science that examines telepathy, clairvoyance, precognition, and psychokinesis (mind over matter). Central to the debate over the existence of psi is of whether independent investigators can replicate reportedly successful psi experiments. One important variable involves the beliefs of experimenters and participants. A preregistered experiment...
Background: Belief in the paranormal is widespread worldwide. Recent surveys suggest that subjective experiences of the paranormal are common. A concise instrument that adequately evaluates beliefs as distinct from experiences does not currently exist. To address this gap, we created the Noetic Experiences and Beliefs Scale (NEBS) which evaluates belief and experience as separate constructs....
Background: Belief in the paranormal is widespread worldwide. Recent surveys suggest that subjective experiences of the paranormal are common. A concise instrument that adequately evaluates beliefs as distinct from experiences does not currently exist. To address this gap, we created the Noetic Experiences and Beliefs Scale (NEBS) which evaluates belief and experience as separate constructs....