August 14, 2026
Rachel E. Jones, Negar Fani, Michael T. Treadway et al.
This study is testing a novel neuromodulation method capable of directly targeting deep brain regions—temporal interference (TI)—to enhance emotion regulation. Pilot data show that, compared to sham stimulation, TI targeting the ventral striatium (VS) during breath-focused mindfulness (BFM) enhances neural markers of reward processing (measured via electroencephalography, EEG) and reduces...
Neuroimage
July 1, 2026
Jonathan S Ryan, Timothy J Mcdermott, Boris Botzanowski et al.
Temporal interference (TI) electrical stimulation is a novel neuromodulation method that can target deep brain structures to enhance the impact of behavioral techniques. We tested the feasibility of TI targeting the ventral striatum (VS) during an emotion regulation practice (breath-focused mindfulness meditation). To assess target engagement, we used electroencephalography (EEG) to measure...
Research Square
February 9, 2026
Jonathan S Ryan, Timothy J Mcdermott, Boris Botzanowski et al.
Temporal interference (TI) electrical stimulation is a novel neuromodulation method that can target deep brain structures to enhance the impact of behavioral techniques. We tested the feasibility of TI in targeting the ventral striatum (VS) in concert with an emotion regulation practice (breath-focused mindfulness meditation). As an assay of target engagement, we used electroencephalography...
Psychosomatic Medicine
April 11, 2018
Gunes Sevinc, Britta K. Hölzel, Javeria A. Hashmi et al.
65 citations
OBJECTIVE: We investigated common and dissociable neural and psychological correlates of two widely used meditation-based stress reduction programs. METHODS: Participants were randomized to the Relaxation Response (RR; n = 18; 56% female) or the Mindfulness-Based Stress Reduction (MBSR; n = 16; 56% female) programs. Both programs use a "bodyscan" meditation; however, the RR program explicitly...
Neuroreport
November 7, 2005
Sara W. Lazar, Catherine E. Kerr, Rachel H. Wasserman et al.
1,707 citations
Previous research indicates that long-term meditation practice is associated with altered resting electroencephalogram patterns, suggestive of long lasting changes in brain activity. We hypothesized that meditation practice might also be associated with changes in the brain's physical structure. Magnetic resonance imaging was used to assess cortical thickness in 20 participants with extensive...