Negar Fani - The Consciousness Library

Using temporal interference non-invasive deep brain stimulation to boost effects of mindfulness meditation in older adolescents

August 14, 2026 Rachel E. Jones, Negar Fani, Michael T. Treadway et al.

This study is testing a novel neuromodulation method capable of directly targeting deep brain regions—temporal interference (TI)—to enhance emotion regulation. Pilot data show that, compared to sham stimulation, TI targeting the ventral striatium (VS) during breath-focused mindfulness (BFM) enhances neural markers of reward processing (measured via electroencephalography, EEG) and reduces...

DOI: 10.17605/osf.io/e3jxc

Ventral striatum temporal interference brain stimulation enhances the reward-positivity event-related potential and reduces anxiety.

Neuroimage July 1, 2026 Jonathan S Ryan, Timothy J Mcdermott, Boris Botzanowski et al.

Temporal interference (TI) electrical stimulation is a novel neuromodulation method that can target deep brain structures to enhance the impact of behavioral techniques. We tested the feasibility of TI targeting the ventral striatum (VS) during an emotion regulation practice (breath-focused mindfulness meditation). To assess target engagement, we used electroencephalography (EEG) to measure...

DOI: 10.1016/j.neuroimage.2026.122101 Full text Anxiety Deep brain stimulation Electroencephalography Reward +2

Ventral striatum temporal interference brain stimulation enhances the reward positivity event-related potential and reduces anxiety.

Research Square February 9, 2026 Jonathan S Ryan, Timothy J Mcdermott, Boris Botzanowski et al.

Temporal interference (TI) electrical stimulation is a novel neuromodulation method that can target deep brain structures to enhance the impact of behavioral techniques. We tested the feasibility of TI in targeting the ventral striatum (VS) in concert with an emotion regulation practice (breath-focused mindfulness meditation). As an assay of target engagement, we used electroencephalography...

DOI: 10.21203/rs.3.rs-8767480/v1 Full text Anxiety Deep brain stimulation Electroencephalography Reward +2

Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.

Research Square December 22, 2025 Negar Fani, Alexa Kondas, Vishwadeep Ahluwalia et al.

Vibration-based therapies are understudied but promising methods for alleviating psychiatric symptoms, particularly when paired with behavioral practices. The potential neuroplastic changes associated with a novel neurostimulation method, sternal vibration, and associations with clinical change remain unknown. We examined effects of sternal vibration paired with mindfulness meditation on change...

DOI: 10.21203/rs.3.rs-8329136/v1 Full text Diffusion-weighted imaging Interoception Neurostimulation Trauma +1

Find your rhythm and regulate: Breath-synced vibration feedback during breath-focused mindfulness reduces respiration variability in trauma-exposed adults.

Journal of Anxiety Disorders June 1, 2025 Timothy J Mcdermott, Greg J Siegle, Alfonsina Guelfo et al. 2 citations

Stress and anxiety are associated with increased autonomic arousal, including altered respiration. Breath-focused mindfulness meditation can reduce stress and anxiety, but trauma-exposed adults with dissociation have difficulty engaging in this practice. Our ongoing clinical trial examines if vibration-augmented breath-focused mindfulness (VABF) can improve outcomes and increase engagement....

DOI: 10.1016/j.janxdis.2025.103008 Full text Anxiety Autonomic Dissociation Physiology +1

ENIGMA-Meditation: Worldwide Consortium for Neuroscientific Investigations of Meditation Practices.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Saampras Ganesan, Fernando A Barrios, Ishaan Batta et al. 6 citations

Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past...

DOI: 10.1016/j.bpsc.2024.10.015 Full text Meditation Mindfulness Consortium Enigma +1

A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Stress Disorder

Frontiers in Psychiatry August 25, 2017 J. Douglas Bremner, Sanskriti Mishra, Carolina Campanella et al. 81 citations

OBJECTIVE: Brain imaging studies in patients with post-traumatic stress disorder (PTSD) have implicated a circuitry of brain regions including the medial prefrontal cortex, amygdala, hippocampus, parietal cortex, and insula. Pharmacological treatment studies have shown a reversal of medial prefrontal deficits in response to traumatic reminders. Mindfulness-based stress reduction (MBSR) is a...

DOI: 10.3389/fpsyt.2017.00157 Traumatic stress Anxiety Mindfulness-based stress reduction Prefrontal cortex +3

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