5 papers in the library · 71 citations · publishing 1978-2018
May 15, 2018 Gordon Claridge 1 citation
This chapter argues that the case for reexamining lysergic acid diethylamide (LSD)-25 as the basis for an animal model of schizophrenia. Schizophrenia is a complex natural disorder of multiple causation and has many features which are almost certainly not part of the core defect of the disease. During its relatively brief history LSD-25 has been the subject of controversy even greater than that...
Routledge eBooks May 15, 2018 Gordon Claridge, Kenneth Clark
This chapter examines the effect of LSD-25 on the covariation between two-flash threshold and skin potential. A Ferranti type CL-64 cathode tube, reduced in intensity with a Kodak neutral density filter and situated at eye-level 2.2 m from the subject, was used to determine the two-flash threshold. During each estimation of the two-flash threshold, a resistance reading coinciding with both the...
Revista Brasileira de Psiquiatria 2017 Letícia O Alminhana, Miguel Farias, Gordon Claridge et al.
It is unclear why some individuals reporting psychotic experiences have balanced lives while others go on to develop mental health problems. The objective of this study was to test if the personality traits of harm avoidance, self-directedness, and self-transcendence can be used as criteria to differentiate healthy from unhealthy schizotypal individuals. We interviewed 115 participants who...
Human Psychopharmacology: Clinical and Experimental September 1, 1994 Gordon Claridge 11 citations
Abstract Despite its early promise as ‘the chemical key to schizophrenia’, and its manifest properties as a psychotomimetic, LSD failed to catch on as a drug model for human psychosis. The reasons for this and the longstanding preference, instead, for the amphetamine model are examined. It is argued that the rejection of LSD was not just a scientific decision, but was influenced by increasing...
Schizophrenia Bulletin 1978 Gordon Claridge 59 citations
Some of the difficulties of trying to establish an animal model of schizophrenia are first considered. Then, after a review of the evidence on the experimental psychopathology of schizophrenia, particularly that concerned with attention and arousal, it is concluded that the core feature which needs to be modeled in animals is some aspect of "input dysfunction." It is argued that, of the...