The afferent vagus nerve transmits interoceptive signals to the brain but a systematic understanding of how vagal signals affect brain-wide neuronal dynamics remains elusive. Here, comprehensive spatiotemporal analyses across the entire mouse brain revealed that vagus nerve stimulation activated neuronal ensembles within the default mode network (DMN). In contrast, vagal-independent mechanisms...
PharmacopsychiatryOctober 2, 2026Masami Murao, Daiki Setoyama, Yasuyuki Matsumoto et al.
Abstract This study investigated the antisuicidal effects of repeated intravenous ketamine in patients with treatment-resistant depression and explored associations between suicidal ideation and temporal changes in selected plasma biomarkers to identify potential biomarkers. This secondary analysis of an open-label trial included outpatients with treatment-resistant depression who received four...
The aim of this paper is to investigate dialectic Darstellung (Representation) as a methodological form in Max Horkheimer’s philosophy of the 1930s, and to clarify its internal logic, with a view to reconstructing his theory of knowledge in a comprehensive manner. Based on a literature review of Horkheimer’s theory of knowledge, the paper identifies several underexamined issues. It argues that...
Perioperative (es)ketamine significantly reduces POD risk but not POND. Subgroup analyses reveal esketamine excels in delirium prevention, while racemic ketamine shows better cognitive protection.
Objective: In this practical study, mindfulness-based “Loving-Kindness and Mindfulness Meditation” was carried out for breast cancer patients. Methods: 60-minute meditation sessions were carried out every two weeks for a total of four sessions. At Month 1 and in the period up to Month 3 after intervention, changes in quality of life (QOL) were assessed using SF-36 v2 for a total of five times....
A number of modern researchers have studied the relationship between religion and health. In every religious tradition, virtues such as self-sacrifice, altruism, and appreciation have been considered quite essential. Arigato-Zen (AZ) (Gratitude Zen) is an easy and simple voice-meditation developed by Dr. Machida, which motivates the feeling of altruism and appreciation. By performing AZ, one is...
This paper explores the relationship between consciousness and future information from a quantum mechanical perspective and proposes an experimental framework for empirical validation. Classical causality suggests that future events do not influence the present; however, non-locality and time symmetry in quantum mechanics suggest that future states may exert an influence on the present.We...