PharmacopsychiatryOctober 2, 2026Masami Murao, Daiki Setoyama, Yasuyuki Matsumoto et al.
Abstract This study investigated the antisuicidal effects of repeated intravenous ketamine in patients with treatment-resistant depression and explored associations between suicidal ideation and temporal changes in selected plasma biomarkers to identify potential biomarkers. This secondary analysis of an open-label trial included outpatients with treatment-resistant depression who received four...
Kitousei-Seishinbyo, or psychosis induced by invocation, was first described by Morita in 1915 as a culture-bound syndrome characterized by possession-like states and personality transformation triggered by prayer or spiritual practices. New psychosocial triggers (e.g., self-improvement seminars, emerging religious groups) have been identified. However, reports of possession-related episodes...
This study aims to investigate the acute and sustained antidepressant effects of repeated ketamine infusions in patients with treatment-resistant depression (TRD), and to identify early metabolomic changes predictive of treatment outcomes using metabolome analyses. This open-label study investigated the effects of four intravenous ketamine infusions (0.5 mg/kg) administered over 2 weeks in 30...