Acute and long-term effects of repeated ketamine infusions in treatment-resistant depression and associated metabolite changes.
Psychiatry and Clinical Neurosciences July 15, 2025 Hitoshi Sakurai, Daiki Setoyama, Takahiro A Kato et al. 1 citation
This study aims to investigate the acute and sustained antidepressant effects of repeated ketamine infusions in patients with treatment-resistant depression (TRD), and to identify early metabolomic changes predictive of treatment outcomes using metabolome analyses. This open-label study investigated the effects of four intravenous ketamine infusions (0.5 mg/kg) administered over 2 weeks in 30...