Here, we present a large-scale, multi-center dataset of combined magnetoencephalographic (MEG) and electroencephalographic (EEG) recordings, along with eye-tracking data and high-resolution structural MRI (T1); complementing with iEEG and fMRI datasets that are shared in accompanying data papers. The data was obtained through an adversarial collaboration between advocates of two neuroscientific...
Science AdvancesMay 8, 2026Max Levinson, Alice Waitt, Katharina Duecker et al.
A longstanding debate in consciousness research concerns whether subjective perceptual experiences arise primarily from activity in sensory cortices or rely critically on inferences made in higher-order brain regions. We address this question using a compelling visual illusion (perceptual filling-in) that isolates neural processes underlying transitions from veridical to illusory conscious...
Different theories explain how subjective experience arises from brain activity1,2. These theories have independently accrued evidence, but have not been directly compared3. Here we present an open science adversarial collaboration directly juxtaposing integrated information theory (IIT)4,5 and global neuronal workspace theory (GNWT)6-10 via a theory-neutral consortium11-13. The theory...
Different theories explain how subjective experience arises from brain activity1,2. These theories have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field3. Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT)4,5 and Global Neuronal Workspace Theory (GNWT)6–10,...
The relationship between conscious experience and brain activity has intrigued scientists and philosophers for centuries. In the last decades, several theories have suggested different accounts for these relationships. These theories have developed in parallel, with little to no cross-talk among them. To advance research on consciousness, we established an adversarial collaboration between...
Although psychostimulants apparently do cross the BBB, it is poorly understood how these hydrophilic and positively charged molecules can pass the blood-brain barrier (BBB). That may be mediated by a genetically still uncharacterized H+/OC antiporter with high activity at the BBB. We studied the uptake of 16 psychostimulants and hallucinogens with hCMEC/D3 cells using the prototypic inhibitor...
Psychostimulants are used therapeutically and for illegal recreational purposes. Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). According to their physicochemical properties, some might also be substrates of polyspecific organic cation transporters (OCTs) that mediate uptake in liver and kidneys for metabolism and...
Abstract The distinguishing practice of mindfulness meditation is the intentional regulation of attention towards the present moment. Mindfulness meditation therefore emphasizes metacognitive functions, in particular the ability to monitor the attentional focus on a moment-by-moment basis. In this study we set out to test whether mindfulness meditation experience is associated with an increased...