How do psychostimulants enter the human brain? Analysis of the role of the proton-organic cation antiporter.
Biochemical Pharmacology October 1, 2021 Alexandra Sachkova, David Alexander Doetsch, Ole Jensen et al. 11 citations
Although psychostimulants apparently do cross the BBB, it is poorly understood how these hydrophilic and positively charged molecules can pass the blood-brain barrier (BBB). That may be mediated by a genetically still uncharacterized H+/OC antiporter with high activity at the BBB. We studied the uptake of 16 psychostimulants and hallucinogens with hCMEC/D3 cells using the prototypic inhibitor...