Carlos Arrabal-Gómez

2 papers in the library · 14 citations · publishing 2024

Papers

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Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats.

Cells April 12, 2024 Carlos Arrabal-Gómez, Rasiel Beltran-Casanueva, Aracelis Hernández-García et al. 7 citations

This study investigates the combined effects of the neuropeptide Y Y1 receptor (NPY1R) agonist [Leu31-Pro34]NPY at a dose of 132 µg and Ketamine at 10 mg/Kg on cognitive functions and neuronal proliferation, against a backdrop where neurodegenerative diseases present an escalating challenge to global health systems. Utilizing male Sprague-Dawley rats in a physiological model, this research...

DOI: 10.3390/cells13080669 Full text Ketamine Npy1r agonist Npy1r-trkb heteroreceptor complex Cognitive functions +9

Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus.

Expert Opinion on Therapeutic Targets April 1, 2024 Carlos Arrabal-Gómez, Pedro Serrano-Castro, Jose Andrés Sánchez-Pérez et al. 7 citations

Major Depressive Disorder (MDD) poses a significant challenge to global health, with current treatments often limited by efficacy and onset delays. This study explores the synergistic antidepressant-like effects of an NPY1R agonist and Ketamine, targeting their neurobiological interactions within the ventral hippocampus. Utilizing a preclinical model, this study administered Neuropeptide Y...

DOI: 10.1080/14728222.2024.2342524 Full text Neurogenesis Antidepressant therapy Npy1r agonist Ventral hippocampus +9