8 papers in the library · 140 citations · publishing 2022-2025
Br J Pain September 4, 2025 Mauro Cavarra, Nadia R. P. W. Hutten, Jan Schepers et al.
A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers.
Journal of psychopharmacology (Oxford, England) October 1, 2024 Valerie Bonnelle, Amanda Feilding, Fernando E. Rosas et al. 16 citations
Non-ordinary states of consciousness induced by psychedelics can be accompanied by so-called "peak experiences," characterized at the emotional level by their intensity and positive valence. These experiences are strong predictors of positive outcomes following psychedelic-assisted therapy, and it is therefore important to better understand their biology. Despite growing evidence that the...
Translational Psychiatry July 15, 2024 Nadia R. P. W. Hutten, Conny W E M Quaedflieg, Natasha L. Mason et al. 16 citations
The repeated use of small doses of psychedelics (also referred to as "microdosing") to facilitate benefits in mental health, cognition, and mood is a trending practice. Placebo-controlled studies however have largely failed to demonstrate strong benefits, possibly because of large inter-individual response variability. The current study tested the hypothesis that effects of low doses of LSD on...
European Journal of Pain August 20, 2023 Mauro Cavarra, Amanda Feilding, Pamela Kryskow et al. 28 citations
Abstract Background Chronic pain is a major cause of suffering and disability and is often associated with psychiatric complications. Current treatments carry the risk of severe side effects and may lead to limited or no relief at all in a relevant portion of this patient population. Preliminary evidence suggests that classical psychedelics (e.g. LSD and psilocybin) may have analgesic effects...
Sci Rep August 17, 2023 Anne Buot, Cecile Pallares, Alina Oganesyan et al. 28 citations
A renewed interest in the use of psychedelics for treating obsessive compulsive disorder (OCD) has emerged in the last 20 years. But pre-clinical and clinical evidence remain scarce, and little is known about the factor determining the magnitude and persistence of the therapeutic effect. We therefore designed a retrospective online survey to explore, in the general population using psychoactive...
Br J Pain July 14, 2022 Valerie Bonnelle, Will J Smith, Natasha L. Mason et al. 26 citations
Analgesic potential of macrodoses and microdoses of classical psychedelics in chronic pain sufferers: a population survey.
Drug Science Policy and Law 2022 Sam Gandy, Valerie Bonnelle, Edward Jacobs et al. 26 citations
Creativity, that is the creation of ideas or objects considered both novel and valuable, is among the most important and highly valued of human traits, and a fundamental aspect of the sciences. Dreams and hypnagogic states have been highly influential in promoting scientific creativity and insight, contributing to some important scientific breakthroughs. Phenomenologically, the latter states of...
Giulia Parola, Catherine Andreu, Valerie Bonnelle et al. preprint
Abstract Self-transcendent experiences, characterized by reduced self-focus and a sense of connection to something greater than oneself, have been linked to positive mental-health outcomes. However, existing induction methods, such as meditation, require sustained training, while pharmacological approaches (e.g., psychedelics) raise legal and ethical issues. Virtual reality (VR) has emerged as...